gene 1,170 words KG: PRKCB 2026-03-27
kind:genesection:genesstate:published
Contents

PRKCB — Protein Kinase C Beta

🧬 Gene Info
Gene SymbolPRKCB
Full NameProtein Kinase C Beta
Chromosome16p12.2
FunctionCell Proliferation and Differentiation: PKCβ signaling regulates cell cycle progression and phenotypic differentiation.
Subcellular Localizationpatterns. In the nervous system, PKCβ plays critical roles in synaptic plasticity, learning and memory, neuronal surviva
Amino Acids50 aa
UniProt ID[P05771](https://www.uniprot.org/uniprot/P05771)
Ensembl IDENSG00000166501
OMIM176970
GeneCardsPRKCB
Human Protein AtlasPRKCB
Associated DiseasesAls, Alzheimer, Cancer, Dementia, Ms, Tumor
InteractionsC3, BST2
KG Connections37 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (3)

APOE-Dependent Autophagy Restoration
Score: 0.61
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (5)

Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

See Also (15)

MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: therapeutic_target
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: associated_with
MAPK3 Gene - ERK1
gene · KG edge: therapeutic_target
EP300 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

PRKCB activates C3
PRKCB expressed_in CLU
PRKCB expressed_in BECN1
PRKCB expressed_in CLUSTERIN
PRKCB associated_with PIK3CG
PRKCB therapeutic_target EGFR
PRKCB therapeutic_target STAT3
PRKCB therapeutic_target CDK4
PRKCB associated_with ALZHEIMER'S DISEASE
PRKCB expressed_in AUTOPHAGY