gene 3,403 words KG: CR1
Contents

CR1 Gene — Complement Component 1q Receptor

🧬 Gene Info
Gene SymbolCR1
Full NameComplement Component 1q Receptor
Chromosome1q32
Protein TypeReceptor
Functionis a gene located on chromosome 1q32.
Primary ExpressionBlood cells (erythrocytes, leukocytes), Brain (microglia, astrocytes), Kidney, Spleen
Molecular Weight250 kDa
Amino Acids1998 aa
Exons38
PathwaysApoptosis, Autophagy, Blood-Brain Barrier, Complement, Dysbiosis
UniProt IDP08578
NCBI Gene ID1378
Ensembl IDENSG00000203797
OMIM120600
GeneCardsCR1
Human Protein AtlasCR1
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, CELL SURVIVAL
Known Drugs/CompoundsStem Cell Therapy
InteractionsABCA7, Actin, AD, AGING, ALZHEIMER, ALZHEIMER DISEASE
KG Connections600 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (28)

CX3CR1-TREM2 Integration for Synapse Pruning Normalization
Score: 0.78
GluN2B-CX3CL1 Axis Controls Microglial Tau Phagocytosis
Score: 0.76
TREM2-CX3CR1 Axis Dysregulation in Microglial Surveillance F
Score: 0.72
Microglia-Mediated Neuroinflammation as a Disease-Amplifying
Score: 0.72
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
CX3CR1 Promoter Methylation Disrupts Neuron-Microglia Cross-
Score: 0.65
CX3CL1-CX3CR1 Mimetic Therapy for Neuroprotection
Score: 0.64
CX3CR1 Agonism Enhances Microglial Phagocytosis of Extracell
Score: 0.63
CX3CR1-Targeted HDAC3 Knockdown in Microglia via AAV9 Delive
Score: 0.62
Cross-Cell Type Synaptic Rescue via Tripartite Synapse Resto
Score: 0.62
Synaptic Pruning Precision Therapy
Score: 0.61
Stratified falsifiers should govern Microglial Priming as Up
Score: 0.59
CX3CR1-Negative Trem2-High Microglial Subset Mediates Female
Score: 0.57
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
H5: Olfactory System as a Toxicant Funnel into Layer II
Score: 0.54
Soluble CX3CL1 cleavage by ADAM proteases disengages fractal
Score: 0.54
CX3CR1-Targeted AntimiR-155 Oligonucleotides for Microglial
Score: 0.53
GluN2B-Regulated Microglial Phagocytosis of Tau Aggregates v
Score: 0.49
CX3CR1 PET with Nano-bodies for Microglial Surveillance Stat
Score: 0.48
CX3CL1 Mimetic Peptide to Disrupt Fractalkine Signaling Dysr
Score: 0.46
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Knowledge Graph (12 edges)

C1QA associated_with CR1
CLU regulates CR1
C1S associated_with CR1
CLUSTERIN regulates CR1
C1Q regulates CR1
CR1 associated_with CFH
CR1 regulates Amyloid-beta 42
CR1 encodes complement receptor 1
rs6656401 regulates CR1
CR1 associated_with C1QA

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