| Gene Symbol | CKB |
| Function | Creatine kinase catalyzes the reversible transfer of a phosphate group from phosphocreatine to ADP |
| Pathways | Circadian Rhythm, Apoptosis |
| UniProt ID | P12277 |
| Ensembl ID | ENSG00000136053 |
| GeneCards | CKB |
| Human Protein Atlas | CKB |
| Energy Buffering | Maintains ATP levels during periods of high demand or stress |
| Energy Shuttle | PCr serves as a spatial energy shuttle from mitochondria to cytosol |
| Neuroprotection | Supports neuronal survival under metabolic stress |
| Synaptic Function | Provides energy for synaptic vesicle cycling and ion pump function |
| Oxidative Stress Protection | Reduces ROS production by maintaining mitochondrial function |
| Associated Diseases | Als, Diabetes, Stroke, translational_neuroscience |
| Interactions | AKT, APOPTOSIS, ARNT, Bcl2, BCL2, BMAL1 |
| SciDEX Hypotheses | Creatine Kinase System Capacity as Neural Energy R |
| KG Connections | 66 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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