gene 1,719 words KG: HNRNPK 2026-03-24
kind:genesection:genesstate:published
Contents

HNRNPK Gene

🧬 Gene Info
Gene SymbolHNRNPK
Chromosome9q21.32
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight51 kDa
Exons17
PathwaysMAPK signaling, Wnt signaling
Ensembl IDENSG00000165119
GeneCardsHNRNPK
Human Protein AtlasHNRNPK
Pre-mRNA processingAlternative splicing regulation
mRNA stabilityBinds to AU-rich elements (AREs) in 3' UTRs
TranslationModulates translation initiation and elongation
Telomere maintenanceAssociates with telomeric DNA
MAPK signalingParticipates in ERK and p38 pathways
Wnt signalingRegulates β-catenin activity
Associated DiseasesAls
InteractionsNDP52, EGR1, LC3, AUTOPHAGY, AND, IFN
KG Connections77 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (14)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
PARP1 Inhibition Therapy
Score: 0.58
Phase-Separated Organelle Targeting
Score: 0.52
Stress Granule Phase Separation Modulators
Score: 0.49
RNA Granule Nucleation Site Modulation
Score: 0.48

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (6)

Packard Center for ALS Research
institution · KG edge: activates
HNRNPA1 Gene
gene · KG edge: expressed_in
EGR1 Gene
gene · KG edge: activates
CKB Gene
gene · KG edge: interacts_with
CALCOCO2 — Calcium Binding and Coiled-Coil Domain 2
gene · KG edge: degrades

Knowledge Graph (12 edges)

HNRNPK degrades PTBP1
HNRNPK degrades TARDBP
HNRNPK activates NDP52
HNRNPK expressed_in HNRNPA1
HNRNPK activates EGR1
HNRNPK interacts_with LC3
HNRNPK degrades CALCOCO2
HNRNPK expressed_in TARDBP
HNRNPK expressed_in PTBP1
HNRNPK degrades NDP52