gene 1,372 words KG: HSPD1 2026-03-24
kind:genesection:genesstate:published
Contents

HSPD1 Gene - Heat Shock Protein Family D Member 1

🧬 Gene Info
Gene SymbolHSPD1
Full NameHeat Shock Protein Family D Member 1
AliasesPage for HSPD1 Gene
Chromosome2q33.1
Protein TypeChaperone
FunctionHSPD1/Hsp60 is a key mitochondrial chaperone
Primary Expressionall tissues with high energy requirements:
PathwaysMitophagy
UniProt IDP10828
NCBI Gene ID3329
Ensembl IDENSG00000134375
OMIM118190
GeneCardsHSPD1
Human Protein AtlasHSPD1
Associated DiseasesAging, Carcinoma
InteractionsCOX4I1, GRIA2, PRKN, CALCOCO2, MFN2, MFF
KG Connections220 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47

Related Analyses (9)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

HSP60 (Heat Shock Protein 60)
protein · KG edge: activates
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: inhibits
Packard Center for ALS Research
institution · KG edge: inhibits
HSP70 Inducer Therapies for Neurodegeneration
idea · KG edge: expressed_in
HSPA1B — Heat Shock Protein 70 Family Member 1B
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

HSPD1 activates COX4I1
HSPD1 activates GRIA2
HSPD1 activates PRKN
HSPD1 contributes_to MAP1LC3B
HSPD1 inhibits CALCOCO2
HSPD1 inhibits MFN2
HSPD1 inhibits MFF
HSPD1 inhibits BECN1
HSPD1 inhibits LONP1
HSPD1 regulates CEBPB