gene

BCL2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BCL2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2857Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

11Debates

Summary

B-cell lymphoma 2 - anti-apoptotic protein critical for neuronal survival in neurodegeneration

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🧬 Gene Info

Gene Symbol	BCL2
Aliases	B-cell lymphoma 2
Protein Family	BCL-2 family (anti-apoptotic subfamily)
Function	Direct BAX/BAK inhibition
Molecular Weight	26 kDa
Pathways	Akt, Apoptosis, Autophagy, BMP signaling, Bh4 Domain
UniProt ID	P10415
GeneCards	BCL2
Human Protein Atlas	BCL2
BH3 domain	Required for interaction with pro-apoptotic family members
Transmembrane domain	Anchors BCL2 to the outer mitochondrial membrane, ER, and nuclear envelope
BH1 domain	Forms part of the hydrophobic pocket that binds BH3 domains
BH2 domain	Contributes to the binding interface for pro-apoptotic proteins
N-terminal flexible region	Contains regulatory sequences
Phosphorylation	BCL2 is phosphorylated on multiple serine/threonine residues
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	Abt263, ABT263, ABT-737, Adcs, berberine, BERBERINE
Interactions	ABCD3, ABP, ACETYL-COA, ACHE, Actin, AD
KG Connections	2852 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: BCL2 — AlphaFold P10415 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (17)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    BCL2["BCL2"] -->|"expressed in"| MITOCHONDRIA["MITOCHONDRIA"]
    BCL2["BCL2"] -.->|"inhibits"| BECN1["BECN1"]
    BCL2["BCL2"] -->|"interacts"| Dementia["Dementia"]
    BCL2["BCL2"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    BCL2["BCL2"] -->|"interacts"| Als["Als"]
    BCL2["BCL2"] -->|"interacts"| Alzheimer["Alzheimer"]
    STAT3["STAT3"] -->|"regulates"| BCL2["BCL2"]
    BMAL1["BMAL1"] -->|"regulates"| BCL2["BCL2"]
    CAT["CAT"] -->|"interacts"| BCL2["BCL2"]
    OPTN["OPTN"] -->|"interacts"| BCL2["BCL2"]
    style BCL2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1923)

Target	Relation	Type	Str
BCL2	encodes	protein	0.00
CASP3	associated_with	gene	1.00
Als	activates	disease	1.00
Cancer	regulates	disease	1.00
Cancer	activates	disease	1.00
Tumor	activates	disease	1.00
CANCER	inhibits	gene	1.00
Lymphoma	activates	disease	1.00
Leukemia	inhibits	disease	1.00
Als	regulates	disease	1.00
Leukemia	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Autophagy	activates	pathway	1.00
Apoptosis	therapeutic_target	pathway	1.00
Apoptosis	activates	pathway	1.00
Tumor	inhibits	disease	1.00
Tumor	therapeutic_target	disease	1.00
Cancer	inhibits	disease	1.00
Apoptosis	inhibits	pathway	1.00
Cancer	therapeutic_target	disease	1.00
CANCER	therapeutic_target	gene	1.00
AKT	therapeutic_target	gene	1.00
Oxidative Stress	activates	pathway	1.00
AUTOPHAGY	activates	gene	1.00
Intrinsic Apoptosis	regulates	pathway	0.98
Cytochrome C Release	regulates	process	0.95
cytochrome c release	regulates	process	0.95
cancer	therapeutic_target	disease	0.95
Cytochrome C	regulates	protein	0.95
Als	inhibits	disease	0.95
Lymphoma	associated_with	disease	0.95
Cancer	associated_with	disease	0.95
chronic lymphocytic leukaemia	therapeutic_target	disease	0.95
AMBRA1	associated_with	protein	0.95
cell survival	regulates	process	0.95
chronic lymphocytic leukemia	therapeutic_target	disease	0.95
acute myeloid leukemia	therapeutic_target	disease	0.92
acute myeloid leukemia	biomarker_for	disease	0.92
Macroautophagy	inhibits	process	0.90
Mitochondrial Apoptosis	regulates	process	0.90
IP3R	binds	protein	0.90
Mitochondrial Outer Membrane Permeabilization	causes	process	0.90
retinal cell death	protects_against	process	0.90
cancer cell death	inhibits	process	0.90
hematologic malignancies	associated_with	disease	0.90
proapoptotic proteins	interacts_with	protein	0.90
apoptosis	regulates	phenotype	0.90
autophagy	inhibits	pathway	0.90
Beclin1	disrupts	protein	0.90
intrinsic apoptosis pathway	upstream_of	pathway	0.90

Incoming (934)

Source	Relation	Type	Str
BCL2	encodes	gene	0.00
APOPTOSIS	therapeutic_target	gene	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
APOPTOSIS	associated_with	gene	1.00
TP53	interacts_with	protein	1.00
ABT263	inhibits	drug	0.95
venetoclax	inhibits	drug	0.95
T3 (triiodothyronine)	increases	drug	0.95
HB68	downregulates	compound	0.92
HB147	downregulates	compound	0.92
Cyclosporine A	downregulates	drug	0.92
Venetoclax	inhibits	drug	0.90
Akt/mTOR pathway	activates	pathway	0.90
gallic acid	associated_with	drug	0.90
BH3-Mimetics	targets	compound	0.90
cardamom nanoemulsion	downregulates	compound	0.90
Bh3-Mimetics	targets	compound	0.90
Abt263	inhibits	drug	0.90
CTSG	inhibits	protein	0.90
sonrotoclax	binds_to	drug	0.90
R-phycoerythrin	associated_with	drug	0.90
venetoclax	binds_to	drug	0.90
Rotenone	downregulates	compound	0.90
PI3K	activates	gene	0.90
PI3K	regulates	protein	0.90
PI3K	therapeutic_target	gene	0.90
STAT3	activates	gene	0.90
OXIDATIVE STRESS	activates	gene	0.90
JAK2/STAT3 Signaling Pathway	upregulates	pathway	0.88
BCL-xL	coexpressed_with	protein	0.87
MCL1	coexpressed_with	protein	0.87
melamine	downregulates	compound	0.87
lisaftoclax	inhibits	drug	0.85
Adcs	targets	compound	0.85
BMAL1	upregulates	gene	0.85
Protacs	targets	compound	0.85
sonrotoclax	inhibits	drug	0.85
Bisphenol F	binds	compound	0.85
SQDS	upregulates	drug	0.85
Nomilin	binds	compound	0.85
LYPLAL1-DT	activates	gene	0.85
miR-195	downregulates	gene	0.85
BPF	binds_to	drug	0.85
Oxidative Stress	downregulates	process	0.85
HB147	targets	compound	0.85
TP53	associated_with	protein	0.85
AKR1B10	regulates	gene	0.85
BAX	associated_with	gene	0.82
nomilin	binds_to	drug	0.80
Sonrotoclax	inhibits	drug	0.80