| Gene Symbol | DRD2 |
| Full Name | Dopamine Receptor D2 |
| Chromosome | 11q23.2 |
| Protein Type | Gpcr |
| Target Class | Gpcr |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Mechanism of Action | Small molecule agonist or antagonist modulating dopamine signaling |
| Primary Expression | Striatum, Substantia nigra, Pituitary, Cortex |
| Druggability | High (0.90) |
| Clinical Stage | Approved |
| Pathways | PI3K |
| UniProt ID | P14416 |
| NCBI Gene ID | 1819 |
| Ensembl ID | ENSG00000149295 |
| GeneCards | DRD2 |
| Human Protein Atlas | DRD2 |
| Associated Diseases | Addiction, Als, Alzheimer, Autism, Bipolar |
| Known Drugs/Compounds | D-520, L-DOPA, levodopa, quinpirole, UNC9995 |
| Interactions | ACHE, Actin, ADRA1A, ADRA1B, Akt, AKT |
| SciDEX Target | View Target Profile (6 clinical trials) |
| SciDEX Hypotheses | Pharmacologic modulation of D2 autoreceptor-Gi/o s |
| KG Connections | 785 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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