| Gene Symbol | PPARGC1A |
| Full Name | PPARG Coactivator 1 Alpha |
| Chromosome | 4p15.31 |
| Protein Type | Transcription Factor |
| Target Class | Transcription Factor |
| Function | PPARGC1A encodes PGC-1α (PPAR gamma coactivator 1-alpha), a transcriptional coactivator that serves as a master regulator of mitochondrial biogenesis and cellular energy metabolism. |
| Mechanism of Action | Small molecule modulator of transcriptional coactivator function |
| Primary Expression | tissues with high metabolic demand: - Brain: Neurons (especially in substantia nigra, hippocampus), [astrocytes](/entities/as |
| Druggability | Low (0.43) |
| Clinical Stage | Approved |
| Pathways | Apoptosis, Autophagy, Cell Cycle, Er Stress, Ferroptosis |
| UniProt ID | Q9UBK2 |
| NCBI Gene ID | 10891 |
| Ensembl ID | ENSG00000109819 |
| OMIM | 604517 |
| GeneCards | PPARGC1A |
| Human Protein Atlas | PPARGC1A |
| Associated Diseases | Als, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Ataxia, athletic_performance |
| Known Drugs/Compounds | Aloe-emodin, glitazones, HBOT, Kaixinsan, Lactiplantibacillus plantarum SG5, metformin |
| Interactions | AKT1, ALS, AMPK, amyloid beta, amyloid-beta, amyotrophic lateral sclerosis |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Perforant Path Presynaptic Terminal Protection Str PGC1α Activation in PV+ Interneurons Bypasses Mito Mitochondrial Coupling Restoration Therapy |
| KG Connections | 978 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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