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gene 1,644 words KG: NFE2L2
Contents

NFE2L2 — Nuclear Factor Erythroid 2-Related Factor 2

🧬 Gene Info
Gene SymbolNFE2L2
Full NameNuclear Factor Erythroid 2-Related Factor 2
Chromosome2q31
Protein FamilybZIP transcription factor family, Cap'n'collar subfamily
PathwaysAutophagy, Chaperone, Epigenetic, Ferroptosis, Glutathione Synthesis
UniProt IDQ16236
NCBI Gene ID4780
Ensembl IDENSG00000116044
OMIM604992
GeneCardsNFE2L2
Human Protein AtlasNFE2L2
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Cancer, Carcinoma, Hepatomegaly, Hepatoprotection
Known Drugs/Compoundsdexamethasone, Dimethyl Fumarate, HBOT, Itaconate, Leucocyanidin, Ml385
InteractionsACOX1, ACTB, Adiponectin, ADIPOQ, AGING, AKT
SciDEX HypothesesNrf2 Pathway Activation Compensates for Progranuli
NRF2 pathway activation to reduce mutant huntingti
NRF2 Pathway Activation for Neuroprotection
KG Connections859 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (15)

NRF2 failure lowers antioxidant reserve and permits recurren
Score: 0.74NRF2 Activation Provides Neuroprotection Across ALS, AD, and
Score: 0.71NRF2-Mediated Proteostatic Convergence: Shared Oxidative Str
Score: 0.70Endothelial NRF2 Activation as a Master Switch for Post-CA B
Score: 0.69NRF2-KEAP1 Pathway Activation to Coordinate Multi-Layer Anti
Score: 0.65HBOT at 1.5 ATA for 60 min induces hormetic response via Nrf
Score: 0.64Nrf2 Pathway Activation Compensates for Progranulin Haploins
Score: 0.63oxLDL/LOX-1/ROS Signaling Induces P2RY12 via Nrf2 Activation
Score: 0.55NRF2 pathway activation to reduce mutant huntingtin aggregat
Score: 0.54Transient Chaperone Priming Prior to Seed Inoculation Preven
Score: 0.54Metabolic Accumulation (Ammonia/Manganese) Triggers IBA1 Dow
Score: 0.52Temporal Nrf2-mTOR Dual Switch Therapy
Score: 0.00Nrf2-NF-κB Oscillatory Circuit Modulation
Score: 0.00Combinatorial Il-1α/TNFα/C1q Antagonism with Selective Agoni
Score: 0.00NRF2 Pathway Activation for Neuroprotection
Score: 0.00

Knowledge Graph (12 edges)

VDR activates NFE2L2
NFE2L2 activates HMOX1
NFE2L2 inhibits ferroptosis
SQSTM1 activates NFE2L2
KEAP1 inhibits NFE2L2
ALOX5 activates NFE2L2
HMOX1 activates NFE2L2
ALOX15 activates NFE2L2
ALOX12 activates NFE2L2
NFE2L2 activates FER

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