| Gene Symbol | NPM1 |
| Aliases | Nucleophosmin |
| Chromosome | 5q35.1 |
| Protein Type | Chaperone |
| Target Class | Chaperone |
| Function | Small molecule modulators of nucleolar function and protein interactions |
| Mechanism of Action | Small molecule modulators of nucleolar function and protein interactions |
| Subcellular Localization | , shuttling between the nucleolus, nucleoplasm, and cytoplasm in response to cellular stress conditions. This traffickin |
| Druggability | Low (0.30) |
| Clinical Stage | Phase III |
| Molecular Weight | 37 kDa |
| Amino Acids | 294 aa |
| Exons | 12 |
| Pathways | Apoptosis |
| UniProt ID | A0A7I2V5J8 |
| Ensembl ID | ENSG00000126016 |
| GeneCards | NPM1 |
| Human Protein Atlas | NPM1 |
| Associated Diseases | Acute Myeloid Leukemia, Als, cancer |
| Known Drugs/Compounds | NSC348884 |
| Interactions | AMYOTROPHIC LATERAL SCLEROSIS, AND, ARHGEF2, ARID1A, C9ORF72, CANCER |
| SciDEX Target | View Target Profile (10 clinical trials) |
| SciDEX Hypotheses | Nucleolar Stress Response Normalization |
| KG Connections | 295 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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