gene 970 words KG: ADORA2B 2026-03-27
kind:genesection:genesstate:published
Contents

ADORA2B Gene

🧬 Gene Info
Gene SymbolADORA2B
Chromosome17p12
Protein TypeReceptor
Functionencodes a G protein-coupled receptor that plays important roles in modulating cellular responses to adenosine.
Primary Expressionastrocytes, microglia, neurons, and endothelial cells of the [
Molecular Weight44 kDa
PathwaysPI3K, MAPK Pathway, NF-κB Pathway, NF-κB
UniProt IDP29274
NCBI Gene ID136
Ensembl IDENSG00000171490
OMIM600446
GeneCardsADORA2B
Human Protein AtlasADORA2B
Gene NameAdenosine A2b Receptor
Protein ClassG protein-coupled receptor, rhodopsin family
Associated DiseasesALS, Inflammation
Known Drugs/CompoundsCaffeine
InteractionsP2RY12, P2RX1, P2RX4, P2RX7, P2RY1, P2RX5
KG Connections55 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

Adenosine-Astrocyte Metabolic Reset
Score: 0.56
CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Microglial Purinergic Reprogramming
Score: 0.48
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.48

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Leukocyte gene expression analysis in COVID-19 patients
exploratory · proposed · Score: 0.90

See Also (10)

Packard Center for ALS Research
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
P2RX1 Gene
gene · KG edge: activates
OCLN — Occludin
gene · KG edge: activates
IL5 Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

ADORA2B activates P2RY12
ADORA2B activates P2RX1
ADORA2B activates P2RX4
ADORA2B activates P2RX7
ADORA2B associated_with CD38
ADORA2B activates P2RY1
ADORA2B activates P2RX5
ADORA2B activates PANX1
ADORA2B inhibits IL5
ADORA2B activates OCLN