gene 991 words KG: ent-gene-a8daf5f4
Contents

AIF1 Gene

🧬 Gene Info
Gene SymbolAIF1
Functionencodes a calcium-binding cytoskeletal adaptor that is strongly enriched in microglia.
PathwaysAutophagy, Inflammasome, Mitophagy, Neuroinflammatory
Ensembl IDENSG00000240065
GeneCardsAIF1
Human Protein AtlasAIF1
Associated DiseasesAging, Als, Alzheimer, PARKINSON DISEASE
Known Drugs/Compoundsrapamycin
InteractionsACTB, AD, AGING, AMPK, AND, ARC
KG Connections462 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (33)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72
Complement C1q Mimetic Decoy Therapy
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
...
Score: 0.68
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Complement C1q Subtype Switching
Score: 0.66
TREM2-Dependent Microglial Senescence Transition
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Complement-Mediated Synaptic Pruning Dysregulation
Score: 0.61
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
← Prevpg 2/2

Related Analyses (7)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (15)

nct05508789
clinical_trial · Pages share 9 hypotheses
LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 9 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 9 hypotheses
remternetug-anti-amyloid-alzheimers
clinical_trial · Pages share 9 hypotheses
LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 9 hypotheses

Knowledge Graph (4 edges)

h-2f032e79df targets ent-gene-a8daf5f4
ent-gene-a8daf5f4 targeted_by h-2f032e79df
ent-gene-a8daf5f4 data_in benchmark_ot_ad_answer_key:AIF1
benchmark_ot_ad_answer_key:AIF1 data_in ent-gene-a8daf5f4

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