gene 991 words KG: AIF1 2026-03-21
kind:genesection:genesstate:published
Contents

AIF1 Gene

🧬 Gene Info
Gene SymbolAIF1
Functionencodes a calcium-binding cytoskeletal adaptor that is strongly enriched in microglia.
PathwaysAutophagy, Inflammasome, Mitophagy, Neuroinflammatory
Ensembl IDENSG00000240065
GeneCardsAIF1
Human Protein AtlasAIF1
Associated DiseasesALS, Aging, Alzheimer
Known Drugs/Compoundsrapamycin
InteractionsASC, NLRP3, SQSTM1, TNF, PYCARD, MAP1LC3B
KG Connections377 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51

Related Analyses (8)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived

See Also (15)

UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 9 hypotheses
remternetug-anti-amyloid-alzheimers
clinical_trial · Pages share 9 hypotheses
nct05508789
clinical_trial · Pages share 9 hypotheses
LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 9 hypotheses
LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 9 hypotheses

Knowledge Graph (12 edges)

AIF1 associated_with ATG7
AIF1 inhibits ASC
AIF1 inhibits NLRP3
AIF1 associated_with GAPDH
AIF1 inhibits SQSTM1
AIF1 inhibits TNF
AIF1 inhibits PYCARD
AIF1 inhibits MAP1LC3B
AIF1 associated_with GFAP
AIF1 associated_with ACTB