gene 759 words KG: ent-gene-47202345
Contents

ARC Gene

🧬 Gene Info
Gene SymbolARC
Full NameActivity-Regulated Cytoskeleton-Associated Protein
Chromosome8q24.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressioncortex and hippocampus with synaptic localization
PathwaysAkt, Complement, Endocytosis, Exocytosis, Long-Term Potentiation
UniProt IDQ7Z594
NCBI Gene ID23237
Ensembl IDENSG00000132740
OMIM602473
GeneCardsARC
Human Protein AtlasARC
Associated DiseasesAls, Alzheimer, Glaucoma, Macular Degeneration, Retinopathy
InteractionsActin, AGING, AIF1, Akt, AKT, ALZHEIMER
SciDEX HypothesesSynaptic Activity-Dependent Protection System
KG Connections245 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (21)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43
APOE-Dependent Autophagy Restoration
Score: 0.89
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
CYP46A1 Overexpression Gene Therapy
Score: 0.77
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
PARP1 Inhibition Therapy
Score: 0.74
Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
Epigenetic Memory Reprogramming for Alzheimer's Disease
Score: 0.61
pg 1/2Next →

Related Analyses (7)

Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

See Also (15)

Alzheimer Indonesia
institution · KG edge: inhibits
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: therapeutic_target
Apoptosis in Neurodegeneration
entity · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
AgRP (Agouti-Related Protein) Neurons
cell · KG edge: produces

Knowledge Graph (4 edges)

h-9ff41c2036 targets ent-gene-47202345
ent-gene-47202345 targeted_by h-9ff41c2036
ent-gene-47202345 data_in benchmark_ot_ad_answer_key:ARC
benchmark_ot_ad_answer_key:ARC data_in ent-gene-47202345

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.