| Gene Symbol | LGALS3 |
| Full Name | Lectin, Galactoside-Binding, Soluble, 3 |
| Chromosome | 14 |
| Function | The LGALS3 gene encodes Lectin, Galactoside-Binding, Soluble, 3, a protein expressed in various brain regions including the cerebral cortex, hippocampus, basal ganglia, and cerebellum. |
| Primary Expression | activated microglia and plays complex roles in neuroinflammation - both promoting and resolving inflammatory responses |
| Pathways | Amyloid, Lipid Metabolism |
| UniProt ID | P17931 |
| Ensembl ID | ENSG00000131981 |
| OMIM | 153619 |
| GeneCards | LGALS3 |
| Human Protein Atlas | LGALS3 |
| Genomic Location | 14q22.3 |
| Approach | Status |
| Small molecule inhibitors | Preclinical |
| Monoclonal antibodies | Preclinical |
| Associated Diseases | AD, ALI, ALS, Alzheimer, Amyotrophic Lateral Sclerosis |
| Known Drugs/Compounds | rapamycin |
| Interactions | CALCOCO2, G3BP1, PEX3, SQSTM1, BCL2, LMNA |
| KG Connections | 952 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |