gene 748 words KG: GLA 2026-03-24
kind:genesection:genesstate:published
Contents

GLA Gene - Alpha-Galactosidase A

🧬 Gene Info
Gene SymbolGLA
AliasesPage for GLA Gene
Protein TypeHydrolase
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight50 kDa
Pathwaysautophagy pathway, epigenetic regulation, oxidative stress response
Ensembl IDENSG00000102393
GeneCardsGLA
Human Protein AtlasGLA
Associated DiseasesALS, Amyotrophic Lateral Sclerosis, Ataxia, Cancer, Cardiovascular
Known Drugs/Compoundsrapamycin
InteractionsCALCINEURIN, ATG12, ATG10, LRRK2, GENES, TREHALOSE
KG Connections284 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (11)

Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.55
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.48

Related Analyses (7)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (10)

Packard Center for ALS Research
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
ATG12 — Autophagy Related 12
gene · KG edge: activates
ATG10 Gene
gene · KG edge: activates
ARSA Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

GLA regulates HSPB8
GLA regulates LAMP2A
GLA regulates MAP1LC3B
GLA regulates MCOLN1
GLA regulates P62
GLA regulates PPARGC1A
GLA regulates SQSTM1
GLA regulates TFEB
GLA regulates TPP1
GLA activates HSPA8