Contents

TPP1 Gene - Tripeptidyl Peptidase 1

🧬 Gene Info

Gene Symbol	TPP1
Aliases	Page for TPP1 Gene, Tripeptidyl Peptidase 1
Chromosome	11p15.4
Protein Family	S9 family serine proteases
Function	It displays tripeptidyl-peptidase activity, cleaving N-terminal tripeptides from various substrates[1].
Molecular Weight	59 kDa
Amino Acids	563 aa
Exons	13
Pathways	Chaperone, Tdp-43, autophagy pathway, oxidative stress response
UniProt ID	O14773
NCBI Gene ID	1201
Ensembl ID	ENSG00000142149
OMIM	607998
GeneCards	TPP1
Human Protein Atlas	TPP1
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Ataxia, Huntington, Neuroblastoma, Parkinson
Known Drugs/Compounds	rapamycin
Interactions	AIF1, amyotrophic lateral sclerosis, AR, ATG, ATG10, ATG12
KG Connections	211 knowledge graph edges
Databases	GeneCards HPA STRING

Knowledge Graph

STIP1 associated_with TPP1

LGALS3 associated_with TPP1

HSPA8 associated_with TPP1

MCOLN1 associated_with TPP1

SQSTM1 associated_with TPP1

SOD1 associated_with TPP1

BCL2 associated_with TPP1

CTSB associated_with TPP1

TPP1 associated_with GLA