gene 644 words KG: DAB1 2026-03-21
kind:genesection:genesstate:published
Contents

DAB1 Gene

🧬 Gene Info
Gene SymbolDAB1
Full NameDisabled-1
Chromosome1p32-p31
Protein FamilyDisabled family
Protein TypeAdaptor Protein
Functionis a key intracellular adaptor protein in the Reelin signaling pathway.
Subcellular LocalizationCytoplasm, postsynaptic densities
Molecular Weight~80 kDa (625 amino acids)
Amino Acids625 aa
PathwaysDendritic Spine, Synaptic Plasticity
UniProt IDD3DX7A
NCBI Gene ID1600
Ensembl IDENSG00000170522
OMIM603448
GeneCardsDAB1
Human Protein AtlasDAB1
Associated DiseasesALS, Alzheimer, Autism, Bipolar, Depression
InteractionsPAFAH1B1, DCX, LIS1, CDK5, RELN, GAIN
KG Connections145 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (15)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (8)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (1)

Reelin pathway defects in human type 2 lissencephaly
exploratory · proposed · Score: 0.70

See Also (6)

Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: regulates
CDK5 Gene
gene · KG edge: associated_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates

Knowledge Graph (12 edges)

DAB1 interacts_with PAFAH1B1
DAB1 associated_with FYN
DAB1 associated_with SRC
DAB1 interacts_with DCX
DAB1 interacts_with LIS1
DAB1 interacts_with CDK5
DAB1 interacts_with RELN
DAB1 associated_with DCX
DAB1 associated_with LIS1
DAB1 associated_with PAFAH1B1