gene 1,741 words KG: DDX1 2026-03-28
kind:genesection:genesstate:publishedevidence:moderate
Contents

DDX1 Gene

🧬 Gene Info
Gene SymbolDDX1
Functionencodes an ATP-dependent RNA helicase that belongs to the highly conserved DEAD-box protein family.
Primary ExpressionHippocampus
Amino Acids724 aa
PathwaysAmyloid
Ensembl IDENSG00000136531
GeneCardsDDX1
Human Protein AtlasDDX1
Helicase activityUnwinding of RNA duplexes
ATPase activityATP hydrolysis provides energy for conformational changes
RNA bindingDirect binding to various RNA substrates
Annealing activityCan also promote RNA-RNA annealing
N-terminal extensionContains nuclear localization signals
Associated DiseasesAlzheimer, Alzheimer'S Disease, Dementia, disease
InteractionsPRMT1, USP1
KG Connections65 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (25)

Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.42
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Phase-Separated Organelle Targeting
Score: 0.52
Membrane Cholesterol Gradient Modulators
Score: 0.52

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

Dementia Australia
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: associated_with
GRN Carrier Resilience: Why Some Mutation Carriers Rema
general · KG edge: associated_with
GBA (Redirect)
redirect · KG edge: associated_with

Knowledge Graph (12 edges)

DDX1 associated_with PSEN1
DDX1 therapeutic_target TGM2
DDX1 associated_with GBA
DDX1 associated_with GRN
DDX1 associated_with TGM2
DDX1 associated_with SORL1
DDX1 associated_with ADAM10
DDX1 associated_with ABCA7
DDX1 biomarker_for GBA
DDX1 biomarker_for GRN