| Gene Symbol | DR5 |
| Chromosome | 5q35.1 |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 52.9 kDa |
| Amino Acids | 477 aa |
| Pathways | Akt, Apoptosis, Cell Cycle, Pi3K |
| UniProt ID | P21918 |
| NCBI Gene ID | 1816 |
| Ensembl ID | ENSG00000169679 |
| GeneCards | DR5 |
| Human Protein Atlas | DR5 |
| Amino acids | 446 |
| D5 has 31 additional residues in C-terminus | | D5 has higher basal activity (constitutive activity) |
| D5 has higher dopamine affinity (~10-fold) | | D5 mRNA shows more widespread brain distribution |
| Associated Diseases | ALS |
| Interactions | EGFR, BAD, AKT, JUN, PI3K, JNK |
| KG Connections | 106 knowledge graph edges |
| Databases | GeneCardsHPASTRING |