gene 587 words KG: BAD 2026-03-22
kind:genesection:genesstate:published
Contents

BAD Gene - BCL2-Associated Agonist of Cell Death

🧬 Gene Info
Gene SymbolBAD
AliasesBCL2L8, BBC2
Chromosome11q13.1
FunctionBAD is a BH3-only pro-apoptotic BCL-2 family member
PathwaysApoptosis, Differentiation, Er Stress, Immune Response, Synaptic Plasticity
UniProt IDQ92934
NCBI Gene ID573
GeneCardsBAD
Human Protein AtlasBAD
ProteinBAD protein
RegulatorInteraction
[BCL2](/genes/bcl2)BH3 binding
[BCL2L1](/genes/bcl2l1) (BCL-XL)Sequestration
AKT/PKBSerine phosphorylation
MAPKSerine phosphorylation
Associated DiseasesAD, ALS, Alzheimer, Cancer, Gastric Cancer
InteractionsDR5, AKT, BID, PUMA, PARK2, PINK1
KG Connections497 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (16)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.55

Related Analyses (11)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

See Also (7)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibits
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: causes
AMBRA1 Gene
gene · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: causes

Knowledge Graph (12 edges)

BAD activates DAG1
BAD activates HSPG2
BAD activates IGF1R
BAD degrades BID
BAD degrades LAMP2
BAD degrades MTOR
BAD degrades PPP1CB
BAD degrades TFRC
BAD activates BAX
BAD activates CASPASES