gene 783 words KG: ELMO1 2026-03-24
kind:genesection:genesstate:published
Contents

ELMO1 - Engulfment and Cell Motility 1

🧬 Gene Info
Gene SymbolELMO1
Full NameEngulfment and Cell Motility 1
AliasesPage for ELMO1, Page for ELMO1 Protein
Chromosome7p14.3
FunctionApoptotic Cell Clearance: ELMO1 mediates the recognition and engulfment of apoptotic cells by phagocytes [2]
Primary ExpressionMicroglia, Macrophages, Brain, Immune cells
Molecular Weight85 kDa
PathwaysAutophagy
UniProt IDQ9Y6I4
NCBI Gene ID2004
Ensembl IDENSG00000126603
OMIM606520
GeneCardsELMO1
Human Protein AtlasELMO1
Symbol [@hochreiterhufford2013] ELMO1 [@martinez2019] [@brahma2016] Full NameEngulfment and Cell Motility 1
Associated DiseasesParkinson's Disease, Alzheimer's Disease, Amyotrophic Lateral Sclerosis
InteractionsLC3, LC3B, AUTOPHAGY
KG Connections12 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (10)

Purinergic Signaling Polarization Control
Score: 0.55
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.46
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Senescent Cell Mitochondrial DNA Release
Score: 0.54

Related Analyses (7)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

See Also (15)

Lysosome Dysfunction in Neurodegeneration
mechanism · KG edge: associated_with
ULK1 — UNC-51 Like Kinase 1
gene · KG edge: regulates
MAP1LC3A Gene
gene · KG edge: activates
ATG5 — Autophagy Related 5
gene · KG edge: regulates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates

Knowledge Graph (12 edges)

ELMO1 activates LC3
ELMO1 regulates ULK1
ELMO1 associated_with LYSOSOME
ELMO1 regulates INFLAMMATION
ELMO1 activates LC3B
ELMO1 associated_with PHAGOCYTOSIS
ELMO1 activates AUTOPHAGY
ELMO1 regulates Infection
ELMO1 regulates Inflammation
ELMO1 activates Autophagy