gene

PHAGOCYTOSIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PHAGOCYTOSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3235Connections

4Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

PHAGOCYTOSIS is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, interacts with. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 963 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	PHAGOCYTOSIS
Aliases	phagocytosis
Associated Diseases	ALS, ALZHEIMER'S DISEASE, Aging, Alzheimer, Alzheimer Disease
Known Drugs/Compounds	RAPAMYCIN, MELATONIN
Interactions	MITOPHAGY, ALZHEIMER'S DISEASE, CYTOKINES, AKT, ASTROCYTES, INFLAMMATION
KG Connections	1927 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| Dementia["Dementia"]
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| Inflammation["Inflammation"]
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| Alzheimer["Alzheimer"]
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| Als["Als"]
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| Neuroinflammation["Neuroinflammation"]
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| Ms["Ms"]
    MICROGLIA["MICROGLIA"] -->|"associated"| PHAGOCYTOSIS["PHAGOCYTOSIS"]
    MSR1["MSR1"] -->|"regulates"| PHAGOCYTOSIS["PHAGOCYTOSIS"]
    BAG3["BAG3"] -->|"activates"| PHAGOCYTOSIS["PHAGOCYTOSIS"]
    C1Q["C1Q"] -->|"activates"| PHAGOCYTOSIS["PHAGOCYTOSIS"]
    style PHAGOCYTOSIS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1264)

Target	Relation	Type	Str
NEUROINFLAMMATION	activates	gene	1.00
Inflammation	activates	disease	1.00
Als	activates	disease	1.00
Neuroinflammation	activates	disease	1.00
Phagocytosis	activates	pathway	1.00
Tumor	activates	disease	1.00
Phagocytosis	regulates	pathway	1.00
AUTOPHAGY	associated_with	gene	1.00
Autophagy	associated_with	pathway	1.00
Phagocytosis	associated_with	pathway	1.00
Als	regulates	disease	1.00
Als	associated_with	disease	1.00
Neurodegeneration	activates	disease	1.00
Inflammation	regulates	disease	1.00
MICROGLIA	activates	gene	1.00
Cancer	activates	disease	1.00
Immune Response	activates	pathway	1.00
Phagocytosis	implicated_in	pathway	1.00
Als	implicated_in	disease	1.00
Inflammation	implicated_in	disease	1.00
Neurodegeneration	implicated_in	disease	1.00
Phagocytosis	inhibits	pathway	1.00
Complement	activates	pathway	1.00
MICROGLIA	regulates	gene	1.00
MICROGLIA	implicated_in	gene	1.00
Alzheimer	activates	disease	0.95
Alzheimer	regulates	disease	0.95
Aging	regulates	disease	0.95
Stroke	activates	disease	0.95
Inflammation	associated_with	disease	0.95
Alzheimer	implicated_in	disease	0.95
Alzheimer	therapeutic_target	disease	0.95
Infection	activates	disease	0.95
AKT	activates	gene	0.90
Nf-Κb	activates	pathway	0.90
Phagocytosis	expressed_in	pathway	0.90
Aging	activates	disease	0.85
Alzheimer	inhibits	disease	0.85
Als	therapeutic_target	disease	0.85
Alzheimer	associated_with	disease	0.85
Als	interacts_with	disease	0.85
Neuroinflammation	implicated_in	disease	0.85
Autophagy	activates	pathway	0.80
Apoptosis	activates	pathway	0.80
Inflammasome	activates	pathway	0.80
Oxidative Phosphorylation	activates	pathway	0.80
ALZHEIMER	activates	gene	0.80
GENES	activates	gene	0.80
STROKE	activates	gene	0.80
MICROGLIA	associated_with	gene	0.80

Incoming (1971)

Source	Relation	Type	Str
C1Q	activates	protein	1.00
LC3	associated_with	gene	1.00
INFLAMMATION	activates	gene	1.00
INFLAMMATION	implicated_in	gene	1.00
INFLAMMATION	regulates	gene	1.00
NEURODEGENERATION	activates	gene	1.00
LC3	activates	gene	1.00
CANCER	activates	gene	1.00
TREM2	activates	gene	1.00
SPP1	regulates	entity	0.95
MICROGLIA	associated_with	gene	0.90
NEURODEGENERATIVE DISEASES	activates	gene	0.90
APOPTOSIS	activates	gene	0.90
AUTOPHAGY	associated_with	gene	0.90
CYTOKINES	activates	gene	0.90
NEURODEGENERATION	implicated_in	gene	0.90
ALZHEIMER	implicated_in	gene	0.90
ALZHEIMER'S DISEASE	implicated_in	gene	0.90
COMPLEMENT	activates	gene	0.90
ALZHEIMER	therapeutic_target	gene	0.90
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.90
MICROGLIA	involved_in	entity	0.85
TREM2 R47H	increases	gene_variant	0.80
TREM2	mediates	gene	0.80
TET2-mutant myeloid cells	enhances	cell_type	0.80
GENES	activates	gene	0.80
INFLAMMATION	associated_with	gene	0.80
ALZHEIMER	regulates	gene	0.80
ALZHEIMER'S DISEASE	regulates	gene	0.80
ATG5	associated_with	gene	0.80
MSR1	regulates	gene	0.72
BAG3	activates	protein	0.72
PARKINSON'S DISEASE	regulates	gene	0.70
TREM2	regulates	gene	0.70
CANCER	therapeutic_target	gene	0.70
ALZHEIMER'S DISEASE	expressed_in	gene	0.70
TREM2	associated_with	gene	0.70
ALZHEIMER'S DISEASE	activates	gene	0.70
NF-ΚB	expressed_in	gene	0.70
PARKINSON'S DISEASE	activates	gene	0.70
GENES	associated_with	gene	0.70
ALZHEIMER'S DISEASE	associated_with	gene	0.70
AMYLOID	associated_with	gene	0.70
MAP1LC3B	associated_with	gene	0.70
INFLAMMATION	expressed_in	gene	0.70
ROS	implicated_in	gene	0.70
CYTOKINES	implicated_in	gene	0.70
SYNAPTIC PRUNING	activates	gene	0.70
GENES	implicated_in	gene	0.70
NEURODEGENERATIVE DISEASES	implicated_in	gene	0.70

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SASP-Driven Microglial Metabolic Reprogramming in Synaptic P	0.638	neurodegeneration	Senolytic therapy for age-related neurod
Stage-Selective TREM2 Agonism — Boosting DAM Phagocytosis in	0.458	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro
Soluble TREM2 (sTREM2) as Therapeutic Mimic — Decoupling Pha	0.452	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro
Microglial TREM2-Mediated Tau Phagocytosis Impairment	0.441	neuroscience	Circuit-level neural dynamics in neurode

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (18)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease [PMID:41109213]	Pilat DJ, Le H, Prokopenko D, Lin CJ, Ei	Neuron	2026
Role of TREM2 in neuroinflammation. [PMID:41213496]	Abdulkhaliq AA, Alasiri G, Almoghrabi Y,	Exp Neurol	2026
Synergistic potential of TREM2 agonists and exercise training in Alzheimer's dis [PMID:41494649]	Zhang J, St Pierre Schneider B, Muguerza	Am J Physiol Endocrinol Metab	2026
Diankuang Mengxing Decoction exerts neuroprotective effects in post-stroke depre [PMID:41534750]	Yang X, Zhao Y, Liu W, Feng J, Wu X et a	J Ethnopharmacol	2026
Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvir [PMID:41576929]	Mateus-Tique J, Lakshmi A, Singh B, Iyer	Cancer Cell	2026
Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystat [PMID:41576952]	Li X, Tang X, Zeng J, Duan L, Hou Z et a	Cell	2026
TREM2 expression level is critical for microglial state, metabolic capacity and [PMID:41580393]	Feiten AF, Dahm K, Schlepckow K, van Len	Nat Commun	2026
Large-scale single-cell analysis and in silico perturbation reveal dynamic evolu [PMID:41617928]	Xia P, Shuang S, Fu D, Liu L, Yang D et	NPJ Precis Oncol	2026
Dissecting genetic and immune drivers of heterogeneous responses to neoadjuvant [PMID:41720086]	Zhao Q, Huang R, Wang C, Hu J, Nie R et	Cancer Cell	2026
TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604]	Yang HC, Deng YS, Zhang J, Zhang T, Song	J Alzheimers Dis	2026
Hierarchical Targeting of TREM2(+) Myeloid Cells via Acid-Triggered OMVs Reprogr [PMID:41945876]	Chen F, Xue Y, Ma X, Chen L, Shao Z et a	Adv Sci (Weinh)	2026
Correction to "A Strategy Involving Microporous Microneedles Integrated with CAR [PMID:41952643]	Unknown	Advanced materials (Deerfield	2026
TREM2 in neurodegeneration and diseases. [PMID:41792456]	["Abdulkhaliq A", "Alasiri G", "Kim B",	Molecular psychiatry	2026
Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721]	Aranda-Abreu GE, Rojas-Durán F, Hernánde	Neurology international	2026
Molecular mechanism of Alzheimer's disease using integrated multi-omics. [PMID:41907842]	Alhusaini M, Mussa BM, Ilce BY, Alhaj H,	Frontiers in aging neuroscienc	2026
Obesity-induced pyroptotic adipocyte death leads to TREM2-dependent macrophage d [PMID:41509917]	Choi C, Lee J, Park G, Namgoong S, Lee Y	iScience	2026
Viral and non-viral cellular therapies for neurodegeneration. [PMID:41585268]	["Srivastav Jyotsna", "Sharma Sachin"]	Frontiers in medicine	2025
Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy. [PMID:20301376]	Adam MP, Bick S, Mirzaa GM, Pagon RA, Wa		1993

PHAGOCYTOSIS

Understanding Entity Pages

Summary

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

nhp-validation-animal-model

Therapeutics

neuroinflammation

Microglial Cells — Cell Type Hierarchy

TREM2 Mechanism Hub

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

GSK-3β in Neurodegeneration

Growth Factor Therapies

Oligodendrocytes

Tau Spreading Mechanism

TREM2 Microglial Signaling Pathway in Neurodegeneration

dendritic-spines

DIAN-TU-001 Trial (NCT01760005)