gene 1,840 words KG: DKK1 2026-03-29
kind:genesection:genesstate:publishedevidence:strong
Contents

DKK1 — Dickkopf WNT Signaling Pathway Inhibitor 1

🧬 Gene Info
Gene SymbolDKK1
Full NameDickkopf WNT Signaling Pathway Inhibitor 1
Chromosome10q21.1
FunctionThis prevents formation of the Wnt-Frizzled-LRP5/6 ternary complex and downstream β-catenin stabilization.
Primary ExpressionBrain (low), Bone, Kidney, Liver
Amino Acids305 aa
PathwaysWNT Signaling, Wnt Signaling, Wnt, Wnt signaling
UniProt IDO94907
NCBI Gene ID2698
Ensembl IDENSG00000107957
OMIM605386
GeneCardsDKK1
Human Protein AtlasDKK1
Associated DiseasesAlzheimer, Dementia, depression
InteractionsSP1, STAT3, NESTIN, Leptin, JNK, PTGS2
KG Connections175 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Purinergic Signaling Polarization Control
Score: 0.55
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Mitochondrial Transfer Pathway Enhancement
Score: 0.44

Related Analyses (10)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (13)

Packard Center for ALS Research
institution · KG edge: regulates
Dementia Australia
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
CTNNB1 — Catenin Beta 1
gene · KG edge: therapeutic_target
CREBBP Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

DKK1 therapeutic_target PPARD
DKK1 therapeutic_target CLDN1
DKK1 therapeutic_target APC
DKK1 therapeutic_target AXIN1
DKK1 therapeutic_target PTGS2
DKK1 therapeutic_target CREBBP
DKK1 therapeutic_target IL10
DKK1 therapeutic_target FOXM1
DKK1 therapeutic_target ATF3
DKK1 therapeutic_target VEGFA