gene 822 words KG: NCAM1 2026-03-21
kind:genesection:genesstate:published
Contents

NCAM1 Gene

🧬 Gene Info
Gene SymbolNCAM1
FunctionNCAM1 encodes a cell adhesion molecule essential for neural development and plasticity.
Molecular Weight220 kDa
PathwaysMAPK, PI3K
Ensembl IDENSG00000149294
GeneCardsNCAM1
Human Protein AtlasNCAM1
Cell adhesionMediates homophilic (NCAM-NCAM) and heterophilic interactions with other cell surface proteins
Neuronal migrationGuides neuronal precursors during brain development
Axon guidanceProvides directional cues for growing axons
SynaptogenesisPromotes formation and maintenance of synapses
Signal transductionActivates intracellular signaling through FGFR, p59fyn, and other kinases
Associated DiseasesALS, Bipolar, Depression, Ms, Schizophrenia
InteractionsRGS1, RAB27A, COL4A1, DISC1, NRG1, GRM3
KG Connections137 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (8)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.48
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.44

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Packard Center for ALS Research
institution · KG edge: associated_with
FGF10 — Fibroblast Growth Factor 10
gene · KG edge: inhibits
ESR1 — Estrogen Receptor Alpha
gene · KG edge: regulates
DRD1 Gene
gene · KG edge: associated_with
DLC1 Gene - Deleted in Liver Cancer 1
gene · KG edge: inhibits

Knowledge Graph (12 edges)

NCAM1 associated_with SCHIZOPHRENIA
NCAM1 associated_with RGS4
NCAM1 associated_with GRIN2B
NCAM1 associated_with DRD1
NCAM1 associated_with TPH2
NCAM1 associated_with GABRA5
NCAM1 associated_with POLG
NCAM1 associated_with TRPM2
NCAM1 associated_with GRM3
NCAM1 associated_with DISC1