Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GABRG2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GABRG2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, causes, inhibits. Associated with ALS, Aging, Als. Connected to 20 entities in the SciDEX knowledge graph.
| Gene Symbol | GABRG2 |
| Full Name | GABA-A Receptor Gamma2 Subunit |
| Chromosome | 5 |
| Protein Type | Channel |
| Function | The GABA-A receptor is a ligand-gated chloride channel that mediates fast inhibitory neurotransmission in the central nervous system. |
| Subcellular Localization | , and trafficking of the receptor |
| UniProt ID | [P18507](https://www.uniprot.org/uniprotkb/P18507/entry) |
| Ensembl ID | ENSG00000102265 |
| GeneCards | GABRG2 |
| Human Protein Atlas | GABRG2 |
| Associated Diseases | ALS, Aging, BLINDNESS, EPILEPSY |
| Interactions | Rb, KCNH2, App, GABRA1, GABRA5 |
| KG Connections | 41 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GABRG2["<b>GABRG2</b>"]
Blindness["Blindness"]
GABRG2 -->|"associated with"| Blindness
Epilepsy{"Epilepsy"}
GABRG2 -->|"associated with"| Epilepsy
Aging{"Aging"}
GABRG2 -->|"inhibits"| Aging
Ms{"Ms"}
GABRG2 -->|"associated with"| Ms
Als{"Als"}
GABRG2 -->|"inhibits"| Als
GABRG2 -->|"associated with"| Aging
GABRG2 -->|"associated with"| Als
ALS{"ALS"}
GABRG2 -->|"causes"| ALS
GABRG2 -->|"causes"| Aging
GABRA1["GABRA1"]
GABRG2 -->|"associated with"| GABRA1
Myelination(["Myelination"])
GABRG2 -->|"associated with"| Myelination
GENES["GENES"]
GABRG2 -->|"associated with"| GENES
GENES -->|"associated with"| GABRG2
GABRA1 -->|"associated with"| GABRG2
EPILEPSY["EPILEPSY"]
EPILEPSY -->|"associated with"| GABRG2
style GABRG2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Gaba-A Receptor | involved_in | receptor | 0.95 |
| Epilepsy | causes | disease | 0.95 |
| Blindness | associated_with | phenotype | 0.90 |
| Blindness | causes | phenotype | 0.90 |
| Optic Atrophy | causes | phenotype | 0.85 |
| GABA receptor signaling | involved_in | pathway | 0.85 |
| KCNH2 | interacts_with | gene | 0.85 |
| BLINDNESS | implicated_in | disease | 0.80 |
| BLINDNESS | causes | disease | 0.80 |
| EPILEPSY | causes | disease | 0.80 |
| Epilepsy | associated_with | disease | 0.65 |
| Aging | inhibits | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| ALS | causes | disease | 0.65 |
| Aging | causes | disease | 0.65 |
| GABRA1 | associated_with | gene | 0.60 |
| Rb | inhibits | protein | 0.60 |
| epilepsy | associated_with | disease | 0.60 |
| NTRK2 | biomarker_for | gene | 0.60 |
| SNCAIP | biomarker_for | gene | 0.60 |
| Myelination | associated_with | pathway | 0.60 |
| GENES | associated_with | gene | 0.60 |
| Myelination | causes | pathway | 0.60 |
| EPILEPSY | associated_with | gene | 0.60 |
| App | inhibits | protein | 0.60 |
| inhibitory neurons | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GABRA1 | interacts_with | gene | 0.85 |
| Haploinsufficiency | associated_with | process | 0.85 |
| GABRA1 | associated_with | gene | 0.60 |
| APOE | biomarker_for | gene | 0.60 |
| CADM1 | biomarker_for | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| EPILEPSY | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| GABRA1 | activates | gene | 0.55 |
| GABRA5 | activates | gene | 0.55 |
| GABRA1 | co_discussed | gene | 0.40 |
| EPILEPSY | co_discussed | disease | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||