gene

GABRG2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABRG2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections
0Hypotheses
0Analyses
29Outgoing
12Incoming

Summary

GABRG2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, causes, inhibits. Associated with ALS, Aging, Als. Connected to 20 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolGABRG2
Full NameGABA-A Receptor Gamma2 Subunit
Chromosome5
Protein TypeChannel
FunctionThe GABA-A receptor is a ligand-gated chloride channel that mediates fast inhibitory neurotransmission in the central nervous system.
Subcellular Localization, and trafficking of the receptor
UniProt ID[P18507](https://www.uniprot.org/uniprotkb/P18507/entry)
Ensembl IDENSG00000102265
GeneCardsGABRG2
Human Protein AtlasGABRG2
Associated DiseasesALS, Aging, BLINDNESS, EPILEPSY
InteractionsRb, KCNH2, App, GABRA1, GABRA5
KG Connections41 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

GABRG2 — GABA-A Receptor Gamma2 Subunit

gene · 929 words

GABRA2 Gene

gene · 2685 words

HNRNPH2 Gene

gene · 2633 words

GABRA3 Gene

gene · 2410 words

GABRA5 Gene

gene · 2239 words

SLC6A11 Gene

gene · 2112 words

Pathway Diagram

graph TD
    GABRG2["<b>GABRG2</b>"]
    Blindness["Blindness"]
    GABRG2 -->|"associated with"| Blindness
    Epilepsy{"Epilepsy"}
    GABRG2 -->|"associated with"| Epilepsy
    Aging{"Aging"}
    GABRG2 -->|"inhibits"| Aging
    Ms{"Ms"}
    GABRG2 -->|"associated with"| Ms
    Als{"Als"}
    GABRG2 -->|"inhibits"| Als
    GABRG2 -->|"associated with"| Aging
    GABRG2 -->|"associated with"| Als
    ALS{"ALS"}
    GABRG2 -->|"causes"| ALS
    GABRG2 -->|"causes"| Aging
    GABRA1["GABRA1"]
    GABRG2 -->|"associated with"| GABRA1
    Myelination(["Myelination"])
    GABRG2 -->|"associated with"| Myelination
    GENES["GENES"]
    GABRG2 -->|"associated with"| GENES
    GENES -->|"associated with"| GABRG2
    GABRA1 -->|"associated with"| GABRG2
    EPILEPSY["EPILEPSY"]
    EPILEPSY -->|"associated with"| GABRG2
    style GABRG2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (29)

TargetRelationTypeStr
Gaba-A Receptorinvolved_inreceptor0.95
Epilepsycausesdisease0.95
Blindnessassociated_withphenotype0.90
Blindnesscausesphenotype0.90
Optic Atrophycausesphenotype0.85

Incoming (12)

SourceRelationTypeStr
GABRA1interacts_withgene0.85
Haploinsufficiencyassociated_withprocess0.85
GABRA1associated_withgene0.60
APOEbiomarker_forgene0.60
CADM1biomarker_forgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found