Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about arf1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ARF1 |
| Protein Family | ARF GTPase family |
| Function | is a small GTP-binding protein that functions as a molecular switch regulating vesicle trafficking between the endoplasmic reticulum (ER) and the Golgi apparatus. |
| Subcellular Localization | Golgi apparatus, ER-Golgi intermediate compartment |
| Molecular Weight | 20.7 kDa |
| Amino Acids | 181 aa |
| UniProt ID | [P84077](https://www.uniprot.org/uniprot/P84077) |
| GeneCards | ARF1 |
| Human Protein Atlas | ARF1 |
| Associated Diseases | neurodegeneration |
| Interactions | Proteins, LRP1, RHOA, STROKE |
| KG Connections | 24 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
arf1["<b>arf1</b>"]
Macrophage["Macrophage"]
arf1 -->|"activates"| Macrophage
FIBROBLASTS["FIBROBLASTS"]
arf1 -->|"activates"| FIBROBLASTS
Proteins(["Proteins"])
arf1 -->|"activates"| Proteins
LRP1(["LRP1"])
arf1 -.->|"inhibits"| LRP1
MITOCHONDRIA["MITOCHONDRIA"]
arf1 -.->|"inhibits"| MITOCHONDRIA
Neuron["Neuron"]
arf1 -.->|"inhibits"| Neuron
RHOA(["RHOA"])
RHOA -->|"activates"| arf1
STROKE(["STROKE"])
STROKE -.->|"inhibits"| arf1
style arf1 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8| Target | Relation | Type | Str |
|---|---|---|---|
| Macrophage | activates | cell_type | 0.50 |
| FIBROBLASTS | activates | concept | 0.50 |
| Proteins | activates | protein | 0.50 |
| LRP1 | inhibits | gene | 0.50 |
| MITOCHONDRIA | inhibits | cell_type | 0.50 |
| Neuron | inhibits | cell_type | 0.50 |
| NEURONS | inhibits | concept | 0.50 |
| ISCHEMIC | inhibits | concept | 0.50 |
| ISCHEMIC STROKE | inhibits | concept | 0.50 |
| LRP1 | activates | gene | 0.50 |
| MITOCHONDRIA | activates | cell_type | 0.50 |
| Astrocyte | activates | cell_type | 0.50 |
| Neuron | activates | cell_type | 0.50 |
| GLYCOLYSIS | inhibits | pathway | 0.50 |
| Astrocytes | inhibits | cell_type | 0.50 |
| Astrocyte | inhibits | cell_type | 0.50 |
| mTOR | activates | entity | 0.50 |
| cancer | activates | disease | 0.50 |
| OBESITY | activates | disease | 0.50 |
| MTORC1 | activates | concept | 0.50 |
| BREAST CANCER | activates | disease | 0.50 |
| MTOR SIGNALING | activates | concept | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||