gene

arf1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about arf1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

99Connections

1Hypotheses

1Analyses

50Outgoing

21Incoming

0Experiments

1Debates

No summary available yet.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	ARF1
Full Name	ADP Ribosylation Factor 1
Protein Family	ARF GTPase family
Function	is a small GTP-binding protein that functions as a molecular switch regulating vesicle trafficking between the endoplasmic reticulum (ER) and the Golgi apparatus.
Subcellular Localization	Golgi apparatus, ER-Golgi intermediate compartment
Molecular Weight	20.7 kDa
Amino Acids	181 aa
UniProt ID	[P84077](https://www.uniprot.org/uniprot/P84077)
GeneCards	ARF1
Human Protein Atlas	ARF1
N-terminal amphipathic helix	Myristoylated, anchors to membranes
Switch I region	Conformational change between GTP/GDP states
Switch II region	Critical for GTP hydrolysis
GTP-binding domains	N, K, and D loops for nucleotide coordination
COPI vesicle formation	Recruits coatomer complex to Golgi membranes
Associated Diseases	neurodegeneration
Interactions	Actin, AND, ASTROCYTE, ASTROCYTES, CANCER, Fus
SciDEX Hypotheses	LRP1-ARF1 Lactylation Inhibitors for Metabolic Neu
KG Connections	75 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ARF1 Gene

gene · 709 words

→

Pathway Diagram

graph TD
    arf1["arf1"]
    Macrophage["Macrophage"]
    arf1 -->|"activates"| Macrophage
    FIBROBLASTS["FIBROBLASTS"]
    arf1 -->|"activates"| FIBROBLASTS
    Proteins(["Proteins"])
    arf1 -->|"activates"| Proteins
    LRP1(["LRP1"])
    arf1 -.->|"inhibits"| LRP1
    MITOCHONDRIA["MITOCHONDRIA"]
    arf1 -.->|"inhibits"| MITOCHONDRIA
    Neuron["Neuron"]
    arf1 -.->|"inhibits"| Neuron
    RHOA(["RHOA"])
    RHOA -->|"activates"| arf1
    STROKE(["STROKE"])
    STROKE -.->|"inhibits"| arf1
    style arf1 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (78)

Target	Relation	Type	Str
MTOR	activates	protein	0.90
mTORC1	activates	protein	0.90
LRP1	interacts_with	gene	0.70
Obesity	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Stroke	inhibits	disease	0.65
Ischemia	inhibits	disease	0.65
RHOA	inhibits	gene	0.60
Glycolysis	inhibits	pathway	0.60
astrocytes	expressed_in	cell_type	0.60
neurons	expressed_in	cell_type	0.60
Mtor	activates	pathway	0.60
Rb	activates	protein	0.60
Fus	inhibits	protein	0.60
autophagy pathway	participates_in	pathway	0.60
LRP1	inhibits	entity	0.60
GCLC	activates	gene	0.60
RNA	activates	gene	0.60
Macrophage	activates	cell_type	0.60
Fibroblast	activates	cell_type	0.60
MTORC1	activates	gene	0.60
CANCER	activates	gene	0.60
LRP1	activates	entity	0.60
ASTROCYTE	inhibits	gene	0.60
MAPK signaling	participates_in	pathway	0.60
SCARB2	activates	gene	0.60
ATG7	expressed_in	gene	0.60
E2F2	expressed_in	gene	0.60
ELAVL1	expressed_in	gene	0.60
GRID2	expressed_in	gene	0.60
MAPK7	expressed_in	gene	0.60
RIPK2	expressed_in	gene	0.60
UHRF1	expressed_in	gene	0.60
MITOCHONDRIA	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
NEURON	inhibits	gene	0.60
STROKE	inhibits	gene	0.60
NEURODEGENERATIVE DISORDERS	inhibits	gene	0.60
necroptosis	participates_in	pathway	0.60
MRPS31	expressed_in	gene	0.60
RHOA	activates	entity	0.60
Neuron	inhibits	cell_type	0.60
Astrocyte	inhibits	cell_type	0.60
macrophages	expressed_in	cell_type	0.60
G6PD	expressed_in	gene	0.60
MAP	expressed_in	gene	0.60
MAPK	expressed_in	gene	0.60
GSH	activates	gene	0.60
Actin	expressed_in	protein	0.60

Incoming (21)

Source	Relation	Type	Str
SCARB2	interacts_with	protein	0.85
MTOR	activates	gene	0.60
SCARB2	activates	gene	0.60
ABCA7	expressed_in	gene	0.60
NEURODEGENERATIVE DISORDERS	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
ASTROCYTE	inhibits	gene	0.60
STROKE	inhibits	gene	0.60
MITOCHONDRIA	inhibits	gene	0.60
NEURON	inhibits	gene	0.60
MTORC1	activates	gene	0.60
CANCER	activates	gene	0.60
AND	activates	gene	0.60
RHOA	inhibits	gene	0.60
GCLC	activates	gene	0.60
RNA	activates	gene	0.60
GSH	activates	gene	0.60
LRP1	inhibits	gene	0.60
AND	inhibits	gene	0.60
STROKE	inhibits	gene	0.50
RHOA	activates	gene	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
LRP1-ARF1 Lactylation Inhibitors for Metabolic Neuroprotecti	0.000	-	Mitochondrial transfer between astrocyte

Mentioning Analyses (1)

Scientific analyses that reference this entity

Mitochondrial transfer between astrocytes and neurons

neurodegeneration | 2026-04-01 | 14 hypotheses Top: 0.833

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Mitochondrial transfer between astrocytes and neurons

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

Related Research

Hypotheses and analyses mentioning arf1 in their description or question text

No additional research found