gene 871 words KG: GFRAL 2026-03-24
kind:genesection:genesstate:published
Contents

GFRAL Gene - GDNF Receptor Alpha Like

🧬 Gene Info
Gene SymbolGFRAL
Full NameGDNF Receptor Alpha Like
AliasesPage for GFRAL Gene, Page for GFRAL Protein
Chromosome6p12.1
Protein TypeReceptor
Functionis a cell surface receptor that belongs to the GDNF receptor family (GFRα).
Primary Expressionspecific neuronal populations: - Substantia nigra pars compacta: Dopaminergic neurons - Ventral tegmental area: Mesolimbic dopamine neurons -
Molecular Weight50 kDa
PathwaysPI3K
UniProt IDQ6UXB5
NCBI Gene ID390538
Ensembl IDENSG00000173137
OMIM615866
GeneCardsGFRAL
Human Protein AtlasGFRAL
Associated DiseasesALS
InteractionsGDNF, GLP1R, ADCY3, Gdnf, AND, HEDGEHOG
KG Connections85 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Vagal Afferent Microbial Signal Modulation
Score: 0.52
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.47

Related Analyses (8)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

See Also (5)

Packard Center for ALS Research
institution · KG edge: activates
Autoimmune Hypothesis in Alzheimer's Disease
hypothesis · KG edge: therapeutic_target
BDNF Gene
gene · KG edge: activates
ADCY3 — Adenylate Cyclase 3
gene · KG edge: activates
GDNF (Redirect)
redirect · KG edge: associated_with

Knowledge Graph (12 edges)

GFRAL inhibits GDNF
GFRAL contributes_to BDNF
GFRAL inhibits GLP1R
GFRAL activates ADCY3
GFRAL expressed_in Brainstem
GFRAL activates GDNF
GFRAL expressed_in GLP1R
GFRAL associated_with GLP1R
GFRAL regulates GDNF
GFRAL associated_with GDNF