| Gene Symbol | GPR146 |
| Full Name | G Protein-Coupled Receptor 146 |
| Chromosome | 7q31.33 |
| Protein Type | Receptor |
| Function | GPR146 signals through G proteins to regulate metabolic pathways: |
| Primary Expression | metabolic tissues and the brain |
| Pathways | MAPK pathway, PI3K |
| UniProt ID | Q96CH4 |
| NCBI Gene ID | 115329 |
| Ensembl ID | ENSG00000173334 |
| GeneCards | GPR146 |
| Human Protein Atlas | GPR146 |
| Gα_s coupling | Activates adenylate cyclase, increasing cAMP levels |
| Gα_i coupling | Inhibits adenylate cyclase in certain cell types |
| β-arrestin signaling | Engages downstream effectors through β-arrestin recruitment |
| Associated Diseases | atherosclerosis, Cardiovascular |
| Interactions | AND, ERK, GENES, LDL, LDLR, LDL RECEPTOR |
| KG Connections | 47 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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