Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LDL RECEPTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | LDL RECEPTOR |
| Amino Acids | 40 aa |
| Pathways | Cholesterol |
| Associated Diseases | Alzheimer'S Disease, disease |
| Interactions | LDLR, GPR146 |
| KG Connections | 29 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
LDL_RECEPTOR["<b>LDL RECEPTOR</b>"]
Proteins["Proteins"]
LDL_RECEPTOR -->|"associated with"| Proteins
ALZHEIMER["ALZHEIMER"]
LDL_RECEPTOR -->|"associated with"| ALZHEIMER
Alzheimer_S_Disease["Alzheimer'S Disease"]
LDL_RECEPTOR -->|"associated with"| Alzheimer_S_Disease
disease["disease"]
LDL_RECEPTOR -->|"associated with"| disease
ALZHEIMER_S["ALZHEIMER'S"]
LDL_RECEPTOR -->|"associated with"| ALZHEIMER_S
PCSK9["PCSK9"]
LDL_RECEPTOR -->|"activates"| PCSK9
Cholesterol["Cholesterol"]
LDL_RECEPTOR -->|"inhibits"| Cholesterol
atherosclerosis["atherosclerosis"]
LDL_RECEPTOR -->|"inhibits"| atherosclerosis
Macrophage["Macrophage"]
LDL_RECEPTOR -->|"inhibits"| Macrophage
MACROPHAGES["MACROPHAGES"]
LDL_RECEPTOR -->|"inhibits"| MACROPHAGES
Cholesterol["Cholesterol"]
LDL_RECEPTOR -->|"expressed in"| Cholesterol
atherosclerosis["atherosclerosis"]
LDL_RECEPTOR -->|"expressed in"| atherosclerosis
Macrophage["Macrophage"]
LDL_RECEPTOR -->|"expressed in"| Macrophage
MACROPHAGES["MACROPHAGES"]
LDL_RECEPTOR -->|"expressed in"| MACROPHAGES
APP_PS1["APP/PS1"]
LDL_RECEPTOR -->|"inhibits"| APP_PS1
Genes["Genes"]
LDL_RECEPTOR -->|"associated with"| Genes
VESICLE_TRAFFICKING["VESICLE TRAFFICKING"]
LDL_RECEPTOR -->|"associated with"| VESICLE_TRAFFICKING
LRP1["LRP1"]
LRP1 -->|"associated with"| LDL_RECEPTOR
LDLR["LDLR"]
LDLR -->|"associated with"| LDL_RECEPTOR
LRP4["LRP4"]
LRP4 -->|"associated with"| LDL_RECEPTOR
LRP8["LRP8"]
LRP8 -->|"associated with"| LDL_RECEPTOR
LRP5["LRP5"]
LRP5 -->|"associated with"| LDL_RECEPTOR
LRP1B["LRP1B"]
LRP1B -->|"associated with"| LDL_RECEPTOR
LRP2["LRP2"]
LRP2 -->|"associated with"| LDL_RECEPTOR
APOER2["APOER2"]
APOER2 -->|"associated with"| LDL_RECEPTOR
late["late"]
late -->|"associated with"| LDL_RECEPTOR
LDLR["LDLR"]
LDLR -->|"activates"| LDL_RECEPTOR
LDLR["LDLR"]
LDLR -->|"inhibits"| LDL_RECEPTOR
GPR146["GPR146"]
GPR146 -->|"inhibits"| LDL_RECEPTOR
FASN["FASN"]
FASN -->|"associated with"| LDL_RECEPTOR| Target | Relation | Type | Str |
|---|---|---|---|
| Proteins | associated_with | protein | 0.50 |
| ALZHEIMER | associated_with | gene | 0.50 |
| Alzheimer'S Disease | associated_with | disease | 0.50 |
| disease | associated_with | disease | 0.50 |
| ALZHEIMER'S | associated_with | concept | 0.50 |
| PCSK9 | activates | concept | 0.50 |
| Cholesterol | inhibits | pathway | 0.50 |
| atherosclerosis | inhibits | disease | 0.50 |
| Macrophage | inhibits | cell_type | 0.50 |
| MACROPHAGES | inhibits | concept | 0.50 |
| Cholesterol | expressed_in | pathway | 0.50 |
| atherosclerosis | expressed_in | disease | 0.50 |
| Macrophage | expressed_in | cell_type | 0.50 |
| MACROPHAGES | expressed_in | concept | 0.50 |
| APP/PS1 | inhibits | concept | 0.50 |
| VESICLE TRAFFICKING | associated_with | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| LRP1 | associated_with | gene | 0.50 |
| LDLR | associated_with | gene | 0.50 |
| LRP4 | associated_with | gene | 0.50 |
| LRP8 | associated_with | gene | 0.50 |
| LRP5 | associated_with | gene | 0.50 |
| LRP1B | associated_with | gene | 0.50 |
| LRP2 | associated_with | gene | 0.50 |
| APOER2 | associated_with | protein | 0.50 |
| late | associated_with | disease | 0.50 |
| LDLR | activates | gene | 0.50 |
| LDLR | inhibits | gene | 0.50 |
| GPR146 | inhibits | gene | 0.50 |
| FASN | associated_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||