gene 679 words KG: GSS 2026-03-12
kind:genesection:genesstate:published
Contents

GSS Gene

🧬 Gene Info
Gene SymbolGSS
Full NameGlutathione Synthetase
AliasesGSH-S
Chromosome20q11.22
FunctionCatalyzes second step of glutathione biosynthesis
Molecular Weight52.4 kDa
Amino Acids474
PathwaysGlutathione biosynthesis, Oxidative stress defense
UniProt IDP16455
NCBI Gene ID2937
Ensembl IDENSG00000100977
OMIM601002
GeneCardsGSS
Human Protein AtlasGSS
CompoundMechanism
Associated DiseasesAD, AMI, ARM, Ms, RA, SS
InteractionsJUN, SLC16A2, PTBP1, P38, SLC7A11, GPX4
KG Connections83 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (5)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Pre-Symptomatic Detection and Intervention Timing in Genetic
validation · proposed · Score: 0.40

See Also (8)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: expressed_in
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: therapeutic_target
Packard Center for ALS Research
institution · KG edge: expressed_in
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: therapeutic_target

Knowledge Graph (12 edges)

GSS activates JUN
GSS activates SLC16A2
GSS implicated_in cancer
GSS activates PTBP1
GSS activates P38
GSS activates SLC7A11
GSS activates GPX4
GSS activates TLR4
GSS expressed_in GFAP
GSS expressed_in BDNF