concept

CYP2E1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CYP2E1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

219Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

CYP2E1 is a concept in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with AD, AMI, ARM. Connected to 113 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	CYP2E1
Key Genes/Proteins	GLUT4, NRF2, OXIDATIVE STRESS
Related Diseases	oxidative stress, Cancer, Anxiety, Dementia, Alzheimer
Related Pathways	Oxidative Stress, oxidative stress response

Wiki Pages (1)

Knowledge base pages for this entity

NRF2 Oxidative Stress Pathway

mechanism · 5315 words

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Pathway Diagram

graph TD
    CYP2E1["CYP2E1"]
    CYP2E1 -->|"inhibits"| GLUT4["GLUT4"]
    CYP2E1 -->|"causes"| oxidative_stress["oxidative stress"]
    CYP2E1 -->|"activates"| NRF2["NRF2"]
    CYP2E1 -->|"activates"| Cancer["Cancer"]
    CYP2E1 -->|"interacts"| Dementia["Dementia"]
    CYP2E1 -->|"activates"| JUN["JUN"]
    CYP2E1 -->|"activates"| ACSL5["ACSL5"]
    CYP2E1 -->|"activates"| SLC16A2["SLC16A2"]
    CYP2E1 -->|"activates"| CANCER["CANCER"]
    CYP2E1 -->|"activates"| MICRORNAS["MICRORNAS"]
    GSS["GSS"] -->|"activates"| CYP2E1
    PER["PER"] -->|"interacts"| CYP2E1
    ROS["ROS"] -->|"expressed in"| CYP2E1
    APOPTOSIS["APOPTOSIS"] -->|"expressed in"| CYP2E1
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"expressed in"| CYP2E1

Outgoing (139)

Target	Relation	Type	Str
GLUT4	inhibits	gene	0.90
oxidative stress	causes	phenotype	0.90
NRF2	activates	protein	0.90
OXIDATIVE STRESS	activates	gene	0.70
Oxidative Stress	activates	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
Cancer	activates	disease	0.65
Anxiety	associated_with	disease	0.65
Dementia	interacts_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Cirrhosis	activates	disease	0.65
Fibrosis	activates	disease	0.65
Inflammation	activates	disease	0.65
Als	activates	disease	0.65
Aging	activates	disease	0.65
Senescence	activates	disease	0.65
Diabetes	regulates	disease	0.65
Metabolic Syndrome	regulates	disease	0.65
Als	regulates	disease	0.65
Nafld	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Fatty Liver	regulates	disease	0.65
Type 2 Diabetes	regulates	disease	0.65
Insulin Resistance	regulates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Neuropathy	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Dementia	therapeutic_target	disease	0.65
Alzheimer	regulates	disease	0.65
Als	associated_with	disease	0.65
Neuroinflammation	regulates	disease	0.65
ALS	associated_with	disease	0.65
JUN	activates	gene	0.60
ACSL5	activates	gene	0.60
SLC16A2	activates	gene	0.60
CANCER	activates	gene	0.60
MICRORNAS	activates	gene	0.60
HTR2C	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
CYP2D6	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
ADRB2	associated_with	gene	0.60
CYP1A2	associated_with	gene	0.60
COMT	associated_with	gene	0.60
MAOB	associated_with	gene	0.60
BCHE	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60

Incoming (80)

Source	Relation	Type	Str
GSS	activates	gene	0.60
GABRA1	associated_with	gene	0.60
DEPRESSION	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
APOE	associated_with	gene	0.60
PER	interacts_with	gene	0.60
GSTP1	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
ROS	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
OXIDATIVE STRESS	expressed_in	gene	0.60
ANXIETY	associated_with	gene	0.60
BCHE	associated_with	gene	0.60
MITOPHAGY	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
PPAR	regulates	gene	0.60
JUN	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
SLC16A2	therapeutic_target	gene	0.60
ACSL5	therapeutic_target	gene	0.60
AND	activates	gene	0.60
MICRORNAS	therapeutic_target	gene	0.60
DIABETES MELLITUS	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
DIABETIC RETINOPATHY	regulates	gene	0.60
AND	regulates	gene	0.60
ACSL5	activates	gene	0.60
MIR-375	activates	gene	0.60
JUN	activates	gene	0.60
SLC16A2	activates	gene	0.60
SLC6A4	associated_with	gene	0.60
ABCG2	associated_with	gene	0.60
CYP1A2	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
MAOB	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
ADRB2	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
COMT	associated_with	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
GENES	interacts_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CYP3A5	associated_with	gene	0.60
CYP2D6	associated_with	gene	0.60
RNA	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found