| Gene Symbol | IL1RN |
| Full Name | Interleukin 1 Receptor Antagonist |
| Chromosome | 2q14.1 |
| Function | encodes the IL-1 receptor antagonist (IL-1Ra), a naturally occurring 152-amino acid secreted glycoprotein |
| Amino Acids | 152 aa |
| Pathways | NF-κB |
| UniProt ID | [P18510](https://www.uniprot.org/uniprot/P18510) |
| Ensembl ID | ENSG00000136689 |
| OMIM | 147679 |
| GeneCards | IL1RN |
| Human Protein Atlas | IL1RN |
| IL-1 blockade | Prevents IL-1R1 signaling by IL-1α and IL-1β |
| NF-κB inhibition | Reduces downstream pro-inflammatory gene expression |
| Glucocorticoid synergy | Enhances anti-inflammatory effects of glucocorticoids |
| Microglial modulation | Shifts microglia from pro-inflammatory (M1) to anti-inflammatory (M2) phenotype |
| Associated Diseases | Als, Inflammation |
| Interactions | NF-ΚB |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |