| Gene Symbol | IL1RN |
| Full Name | Interleukin 1 Receptor Antagonist |
| Chromosome | 2q14.1 |
| Function | encodes the IL-1 receptor antagonist (IL-1Ra), a naturally occurring 152-amino acid secreted glycoprotein |
| Amino Acids | 152 aa |
| Pathways | NF-κB |
| UniProt ID | [P18510](https://www.uniprot.org/uniprot/P18510) |
| Ensembl ID | ENSG00000136689 |
| OMIM | 147679 |
| GeneCards | IL1RN |
| Human Protein Atlas | IL1RN |
| Receptor binding | IL-1Ra binds IL-1R1 with similar affinity to IL-1α and IL-1β, but without activating downstream signaling |
| No signaling | The IL-1Ra/IL-1R1 complex cannot recruit the IL-1 receptor accessory protein (IL-1RAP), blocking signal transduction |
| Four isoforms | Generated by alternative splicing — a secreted form (sIL-1Ra) and three intracellular forms (icIL-1Ra1, icIL-1Ra2, icIL-1Ra3) |
| Expression regulation | Low basal expression in most tissues; strongly upregulated by IL-1β, TNF-α, and TLR ligands |
| Associated Diseases | Als, Inflammation |
| Interactions | NF-ΚB |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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