gene 651 words KG: IL10 2026-03-24
kind:genesection:genesstate:published
Contents

IL10 — Interleukin 10

🧬 Gene Info
Gene SymbolIL10
Full NameIL10 — Interleukin 10
Chromosome1q31.3
Protein TypeLigand
Target ClassLigand
FunctionRecombinant protein replacement or monoclonal antibody modulation
Mechanism of ActionRecombinant protein replacement or monoclonal antibody modulation
DruggabilityLow (0.36)
Clinical StagePhase II
Amino Acids160 aa
Exons5
PathwaysJAK-STAT pathway
UniProt IDQ6FGW4
NCBI Gene ID3586
GeneCardsIL10
Human Protein AtlasIL10
Associated DiseasesALS, Alzheimer, Alzheimer's disease, Crohn'S Disease, Hypertension
Known Drugs/CompoundsViral Therapeutic Approach
InteractionsAHR, TGFB1, ATG16L1, LC3, IL18, TNF
SciDEX TargetView Target Profile (8 clinical trials)
KG Connections587 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (25)

Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.41
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Ganglioside Rebalancing Therapy
Score: 0.50

Related Analyses (8)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived

Related Experiments (2)

IL-10 deficiency and VLC ceramide accumulation in inflammato
validation · proposed · Score: 0.90
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (11)

Alzheimer Indonesia
institution · KG edge: co_discussed
AXIN1 Gene
gene · KG edge: therapeutic_target
ATG16L1 - Autophagy Related 16 Like 1
gene · KG edge: interacts_with
ATF3 Gene
gene · KG edge: therapeutic_target
APC Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

IL10 inhibits Immune Cell Activation
IL10 inhibits Cytokine Production
IL10 regulates Sphingolipid Metabolism
IL10 inhibits SPHINGOLIPID METABOLISM
IL10 regulates MACROPHAGE
IL10 regulates MICROGLIA
IL10 inhibits Inflammation
IL10 protects_against Inflammatory Bowel Disease
IL10 associated_with neurodegeneration
IL10 interacts_with AHR