gene 651 words KG: IL10
Contents

IL10 — Interleukin 10

🧬 Gene Info
Gene SymbolIL10
Full NameInterleukin 10
Chromosome1q31.3
Protein TypeLigand
Target ClassLigand
FunctionRecombinant protein replacement or monoclonal antibody modulation
Mechanism of ActionRecombinant protein replacement or monoclonal antibody modulation
DruggabilityLow (0.36)
Clinical StagePhase II
Amino Acids160 aa
Exons5
PathwaysJAK-STAT pathway
UniProt IDQ6FGW4
NCBI Gene ID3586
GeneCardsIL10
Human Protein AtlasIL10
Associated DiseasesAls, Alzheimer, Alzheimer's disease, Crohn'S Disease, Hypertension
Known Drugs/CompoundsViral Therapeutic Approach
InteractionsACE, AHR, AKT, ALZHEIMER, AMYLOID, APOPTOSIS
SciDEX TargetView Target Profile (8 clinical trials)
SciDEX HypothesesEarly Immune Challenge Tolerance Induction
KG Connections541 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (25)

Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Ocular Immune Privilege Extension
Score: 0.69
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69
Ganglioside Rebalancing Therapy
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.68
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Sphingolipid Metabolism Reprogramming
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Multi-Modal Stress Response Harmonization
Score: 0.76
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
Smartphone-Detected Motor Variability Correction
Score: 0.74
Retinal Vascular Microcirculation Rescue
Score: 0.72
Microbial Inflammasome Priming Prevention
Score: 0.65
Vagal Afferent Microbial Signal Modulation
Score: 0.62
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
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Related Analyses (7)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived

Related Experiments (2)

IL-10 deficiency and VLC ceramide accumulation in inflammato
validation · proposed · Score: 0.90
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (11)

Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: therapeutic_target
ACE Gene
gene · KG edge: associated_with
AKT1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

AHR interacts_with IL10
IL10 interacts_with AHR
IL10 interacts_with TGFB1
TGFB1 interacts_with IL10
IGF1R activates IL10
IL10 inhibits IL1B
IL10 inhibits TNFA
TYK2 associated_with IL10
IL10 associated_with DNMT3A
IL10 activates osteoblastogenesis

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