gene 875 words KG: KCNH2 2026-03-21
kind:genesection:genesstate:published
Contents

KCNH2 — Potassium Voltage-Gated Channel Subfamily H Member 2

🧬 Gene Info
Gene SymbolKCNH2
Full NamePotassium Voltage-Gated Channel Subfamily H Member 2
Protein TypeChannel
FunctionThe S4 segment serves as the voltage sensor, while the S5-S6 pore region forms the ion conduction pathway.
Primary Expressionvarious regions including the hippocampus, cortex, thalamus, and basal ganglia
Ensembl IDENSG00000196878
GeneCardsKCNH2
Human Protein AtlasKCNH2
Associated DiseasesALS, Long QT Syndrome, Long-Qt Syndrome, epilepsy
InteractionsGABRG2, HCN1
KG Connections49 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.47
HCN1-Mediated Resonance Frequency Stabilization Therapy
Score: 0.44
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.44

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (13)

Packard Center for ALS Research
institution · KG edge: therapeutic_target
SCN5A Gene
gene · KG edge: therapeutic_target
PPARG — Peroxisome Proliferator-Activated Receptor Gamm
gene · KG edge: therapeutic_target
LMNA Gene
gene · KG edge: therapeutic_target
KCNQ1 (KV7.1)
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

KCNH2 provides_data_for ds-83b31ef18d49
KCNH2 therapeutic_target IDH1
KCNH2 therapeutic_target TP53
KCNH2 therapeutic_target SCN5A
KCNH2 therapeutic_target IL1B
KCNH2 therapeutic_target KCNQ1
KCNH2 therapeutic_target TNF
KCNH2 therapeutic_target CALM1
KCNH2 therapeutic_target LMNA
KCNH2 therapeutic_target HRAS