gene 3,426 words KG: HRAS
Contents

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)

🧬 Gene Info
Gene SymbolHRAS
Full Namehras
Chromosome11p15.5
Protein TypeGene
Functionis a prototype member of the Ras family of small GTPases that functions as a molecular switch in intracellular signaling pathways.
Primary Expressionmedium spiny neurons of the striatum and in dopaminergic neurons of the substantia nigra pars compacta
Amino Acids188 aa
Exons6
PathwaysNF-ÎșB
UniProt IDP01112
NCBI Gene ID3265
Ensembl IDENSG00000174775
GeneCardsHRAS
Human Protein AtlasHRAS
Associated DiseasesALS, Cancer, Fibrosis, Inflammation, Ms
InteractionsGMM, RAGE, AKT, INFLAMMATION, IMMUNE INFILTRATION, GENES
KG Connections261 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (15)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.84
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.77
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.75
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73

Related Analyses (9)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

See Also (8)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: therapeutic_target
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: therapeutic_target
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: associated_with
CYCS
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

HRAS therapeutic_target DRD2
HRAS therapeutic_target PPARG
HRAS therapeutic_target IDH2
HRAS therapeutic_target CASP3
HRAS therapeutic_target VEGFA
HRAS therapeutic_target CDK4
HRAS therapeutic_target CDKN1A
HRAS therapeutic_target JUN
HRAS regulates PPARG
HRAS regulates GAPDH

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