gene 1,523 words KG: LGMN 2026-03-27
kind:genesection:genesstate:published
Contents

LGMN Gene

🧬 Gene Info
Gene SymbolLGMN
Full NameLegumain (Asparagine Endopeptidase)
AliasesLegumain
Chromosome14q32.12
Protein TypeCysteine protease, peptidase family C13
FunctionThe structure features
Primary ExpressionUbiquitous, high in kidney, brain, immune cells
Subcellular Localization3:
Molecular Weight56 kDa (proenzyme), 46 kDa (active enzyme)
PathwaysAutophagy, Chaperone, Ferroptosis
UniProt IDQ99538
NCBI Gene ID5648
Ensembl IDENSG00000100600
OMIM607216
GeneCardsLGMN
Human Protein AtlasLGMN
Associated Diseasesneurodegeneration
InteractionsHK2, STAT3, ALZHEIMER, AND, NEURODEGENERATIVE DISEASES, ALZHEIMER'S DISEASE
KG Connections34 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.53
Senescence-Associated Myelin Lipid Remodeling
Score: 0.51
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.48

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Longevity and Rejuvenation Therapies Landscape
therapeutic · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
SQSTM1 — Sequestosome 1 (p62)
gene · KG edge: associated_with
KEAP1 — Kelch-Like ECH-Associated Protein 1
gene · KG edge: associated_with

Knowledge Graph (12 edges)

LGMN interacts_with HK2
LGMN associated_with SQSTM1
LGMN associated_with KEAP1
LGMN associated_with CTSD
LGMN activates STAT3
LGMN interacts_with Ms
LGMN activates Ischemia
LGMN activates Ferroptosis
LGMN activates Autophagy
LGMN activates Chaperone