gene 1,994 words KG: LYST
Contents

LYST Gene — Lysosomal Trafficking Regulator

🧬 Gene Info
Gene SymbolLYST
Chromosome1q42.1-q42.2
Protein TypeRegulatory Protein, Lysosomal Function
Functionencodes a large cytosolic protein that plays critical roles in lysosomal function, vesicle trafficking, and autophagy.
Primary Expressionvirtually all tissues, with highest expression in:
Subcellular LocalizationLYST is primarily localized to:
Amino Acids801 aa
PathwaysAutophagy, Exocytosis
UniProt IDQ99698
NCBI Gene ID1130
Ensembl IDENSG00000143669
OMIM606897
GeneCardsLYST
Human Protein AtlasLYST
Gene NameLysosomal Trafficking Regulator
Associated Diseasesneurodegeneration
KG Connections12 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (20)

RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.41
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.62
APOE-Dependent Autophagy Restoration
Score: 0.61

Related Analyses (10)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

See Also (7)

Packard Center for ALS Research
institution · KG edge: regulates
CTSD — Cathepsin D
gene · KG edge: regulates
CLN5 Gene - Ceroid Lipofuscinosis, Neuronal 5
gene · KG edge: regulates
ATG5 — Autophagy Related 5
gene · KG edge: regulates
ATG1
gene · KG edge: regulates

Knowledge Graph (12 edges)

LYST regulates ATG1
LYST regulates ATG5
LYST regulates CLN5
LYST regulates CTSD
LYST regulates AND
LYST regulates MICROTUBULES
LYST regulates ATG9
LYST regulates AUTOPHAGY
LYST regulates Ms
LYST regulates Als