gene

ATG1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections

0Hypotheses

0Analyses

41Outgoing

19Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	ATG1 (ULK1 in mammals)
Full Name	Unc-51 Like Autophagy Activating Kinase 1
Aliases	ATG1, atg1
Chromosome	12q13.12
Protein Type	Serine/Threonine Kinase
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	~105 kDa
Pathways	Exocytosis
UniProt ID	[Q9Y4P5](https://www.uniprot.org/uniprot/Q9Y4P5)
ULK1	Catalytic serine/threonine kinase that initiates autophagy signaling
ATG13	Regulatory subunit that enhances ULK1 activity and serves as a scaffold
FIP200	Scaffold protein that recruits downstream effectors
ATG101	Stabilizing subunit that protects ATG13 from degradation
Associated Diseases	Ataxia, Neurodegeneration
Interactions	ULK1, P62, PI3K, ATG13, ATG5, MTOR
KG Connections	60 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (15)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ATG1["ATG1"] -->|"activates"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ATG1["ATG1"] -->|"activates"| Ms["Ms"]
    style Ms fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ATG1["ATG1"] -->|"implicated in"| Ataxia["Ataxia"]
    style Ataxia fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ATG1["ATG1"] -->|"implicated in"| Neurodegeneration["Neurodegeneration"]
    style Neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ATG1["ATG1"] -->|"associated"| ULK2["ULK2"]
    style ULK2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ATG1["ATG1"] -->|"activates"| ULK1["ULK1"]
    style ULK1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ATG1["ATG1"] -->|"activates"| Mitophagy["Mitophagy"]
    style Mitophagy fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    ATG["ATG"] -->|"component of"| ATG1["ATG1"]
    style ATG fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ULK1_1["ULK1"] -->|"co expressed with"| ATG1["ATG1"]
    style ULK1_1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    AMPK["AMPK"] -->|"associated"| ATG1["ATG1"]
    style AMPK fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    MITOPHAGY["MITOPHAGY"] -->|"activates"| ATG1["ATG1"]
    style MITOPHAGY fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    P62["P62"] -->|"activates"| ATG1["ATG1"]
    style P62 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style ATG1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (41)

Target	Relation	Type	Str
Als	activates	disease	0.75
Ms	activates	disease	0.65
ALS	activates	disease	0.65
Ataxia	implicated_in	disease	0.65
Neurodegeneration	implicated_in	disease	0.65
Ms	regulates	disease	0.65
Als	regulates	disease	0.65
ULK2	associated_with	gene	0.60
ULK1	activates	gene	0.60
P62	activates	gene	0.60
PI3K	interacts_with	gene	0.60
ATG13	interacts_with	gene	0.60
ATG5	interacts_with	gene	0.60
SCA3	implicated_in	gene	0.60
RAB7	implicated_in	gene	0.60
ATG12	regulates	gene	0.60
ULK1	regulates	gene	0.60
MTOR	activates	gene	0.60
ULK1	associated_with	entity	0.60
ATG5	associated_with	gene	0.60
CLN5	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
Mitophagy	activates	pathway	0.60
Autophagy	associated_with	pathway	0.60
AMPK	associated_with	gene	0.60
ATG	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
Autophagy	interacts_with	pathway	0.60
Pi3K	interacts_with	pathway	0.60
MITOPHAGY	activates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
Mtor	activates	pathway	0.60
Autophagy	activates	pathway	0.60
AND	associated_with	gene	0.60
MICROTUBULES	regulates	gene	0.60
ATG9	associated_with	gene	0.60
Exocytosis	regulates	pathway	0.60
T Cell	activates	cell_type	0.60
T Cell	expressed_in	cell_type	0.55
mitophagy	activates	pathway	0.50

Incoming (19)

Source	Relation	Type	Str
ATG	component_of	gene	0.80
ULK1	co_expressed_with	protein	0.75
ULK1	activates	gene	0.60
P62	activates	gene	0.60
ULK2	associated_with	gene	0.60
ATG5	regulates	gene	0.60
RAB5	implicated_in	gene	0.60
ULK1	regulates	gene	0.60
LYST	regulates	gene	0.60
AMPK	associated_with	gene	0.60
MITOPHAGY	activates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
ENDOSOME	implicated_in	gene	0.60
NEURODEGENERATION	implicated_in	gene	0.60
ENDOSOMES	implicated_in	gene	0.60
AMPK	activates	gene	0.60
AND	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
AND	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ATG1

Understanding Entity Pages

Wiki Pages (15)

ATG1

mTOR Signaling in Neurodegeneration

Autophagy-Impaired Neurons

spermidine-neurodegeneration

ATG17A

ATG17 Gene

ULK1 — UNC-51 Like Kinase 1

ULKL1 (ULK5) Gene

mTOR Signaling Pathway in Neurodegeneration

ULK2 Gene

ULK2 Protein

ATG16L1 - Autophagy Related 16 Like 1

atg101

ULK1 — ULK1 Protein

Genes

Pathway Diagram

Outgoing (41)

Incoming (19)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)