gene 680 words KG: CLN5 2026-03-24
kind:genesection:genesstate:published
Contents

CLN5 Gene - Ceroid Lipofuscinosis, Neuronal 5

🧬 Gene Info
Gene SymbolCLN5
AliasesPage for CLN5 Gene
Chromosome13q22.3
Protein FamilyCLN5 family
FunctionIt contains a signal peptide for secretion and is targeted to lysosomes via mannose-6-phosphate-independent pathways[2].
Molecular Weight48 kDa
Amino Acids407 aa
Exons4
PathwaysAutophagy
UniProt IDQ9NWW5
NCBI Gene ID1203
Ensembl IDENSG00000157540
OMIM608096
GeneCardsCLN5
Human Protein AtlasCLN5
Associated Diseasesneurodegeneration
InteractionsCR1, PARP1, SIGLEC9, SIRPA, TPP1, VEGFB
KG Connections36 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (2)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (7)

Packard Center for ALS Research
institution · KG edge: expressed_in
LYST Gene — Lysosomal Trafficking Regulator
gene · KG edge: regulates
CTSD — Cathepsin D
gene · KG edge: regulates
ATG5 — Autophagy Related 5
gene · KG edge: associated_with
ATG1
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CLN5 regulates CTSD
CLN5 interacts_with CR1
CLN5 interacts_with PARP1
CLN5 interacts_with SIGLEC9
CLN5 interacts_with SIRPA
CLN5 interacts_with TPP1
CLN5 interacts_with VEGFB
CLN5 associated_with CTSH
CLN5 associated_with SIRPA
CLN5 associated_with TMEM106B