gene 1,311 words KG: EZH2 2026-03-28
kind:genesection:genesstate:published
Contents

EZH2 — Enhancer of Zeste Homolog 2

🧬 Gene Info
Gene SymbolEZH2
Full NameEnhancer of Zeste Homolog 2
AliasesKMT6, KMT6A, ENX-1
Chromosome7q36.1
FunctionH3K27me3 is the transcriptionally repressive mark that defines Polycomb-silenced chromatin.
Molecular Weight85.4 kDa
Amino Acids746 aa
Exons20
PathwaysAutophagy, Circadian Rhythm, Epigenetic, Histone Modification, Inflammasome
UniProt IDQ15910
NCBI Gene ID2146
Ensembl IDENSG00000106462
OMIM601573
GeneCardsEZH2
Human Protein AtlasEZH2
Associated DiseasesCancer, Infection, Inflammation, Prostate Cancer, major depressive disorder, neurodegeneration
Known Drugs/CompoundsEPZ6438
InteractionsTBK1, STING, IRF3, EED, MYC, BRAF
KG Connections286 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (16)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56

Related Analyses (7)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · completed

Related Experiments (6)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
CRISPR Gene Correction Approaches for CBS/PSP
clinical · proposed · Score: 0.40
Alpha-Synuclein Staging and Spreading in DLB — Spatial Propa
validation · proposed · Score: 0.40
DLB Cognitive Fluctuation Mechanism Experiment
clinical · proposed · Score: 0.40
DLB Treatment Response Biomarkers — Predicting Cholinesteras
clinical · proposed · Score: 0.40

See Also (13)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
BMP2 — Bone Morphogenetic Protein 2
gene · KG edge: activates
BDNF Gene
gene · KG edge: activates
BCL2 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

EZH2 activates TBK1
EZH2 activates STING
EZH2 activates IRF3
EZH2 therapeutic_target NSD3
EZH2 activates Chromatin Remodeling
EZH2 biomarker_for GAIN
EZH2 biomarker_for SOX2
EZH2 biomarker_for OVERVIEW
EZH2 regulates H3K27me3
EZH2 associated_with major depressive disorder