gene 1,927 words KG: MAF 2026-03-25
kind:genesection:genesstate:published
Contents

MAF - MAFA BZIP Transcription Factor

🧬 Gene Info
Gene SymbolMAF
Chromosome16q22.1
Protein TypeTranscription Factor
Functionis a member of the MAF family of transcription factors, belonging to the larger AP-1 superfamily of basic leucine zipper (bZIP) proteins.
Molecular Weight~42 kDa
Amino Acids370 aa
PathwaysCo-inhibitory Gene Module, Endocytosis
UniProt IDQ9UHV9
NCBI Gene ID4094
Ensembl IDENSG00000185340
OMIM610266
GeneCardsMAF
Human Protein AtlasMAF
Gene NameMAFA BZIP Transcription Factor
Protein Length370 amino acids
Associated DiseasesALS, Alzheimer, Atherosclerosis, Autoimmune, Cancer
InteractionsCD8, CD4, PRDM1, KEAP1, NRF2, P62
KG Connections197 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (3)

Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.51
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.50
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.38

Related Analyses (1)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Experiment: Multi-Ethnic PD GWAS
clinical · proposed · Score: 0.40
CRISPR Gene Correction Approaches for CBS/PSP
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40

See Also (12)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: associated_with
CD4 Gene
gene · KG edge: activates
CD38 Molecule (CD38)
gene · KG edge: associated_with

Knowledge Graph (12 edges)

MAF activates MERTK
MAF inhibits CD8
MAF inhibits CD4
MAF inhibits PRDM1
MAF regulates C1Q
MAF activates KEAP1
MAF activates NRF2
MAF activates P62
MAF interacts_with NRF2
MAF therapeutic_target KEAP1