gene 1,181 words KG: MFSD2A 2026-03-21
kind:genesection:genesstate:published
Contents

MFSD2A - Major Facilitator Superfamily Domain Containing 2A

🧬 Gene Info
Gene SymbolMFSD2A
Full NameMajor Facilitator Superfamily Domain Containing 2A
AliasesPage for MFSD2A
Chromosome1p34.2
Protein TypeTransporter
Functionencodes a sodium-dependent lysophosphatidylcholine (LPC) transporter that is essential for blood-brain barrier integrity and brain lipid composition.
Amino Acids530 aa
Exons14
PathwaysBlood-Brain Barrier
Ensembl IDENSG00000168389
GeneCardsMFSD2A
Human Protein AtlasMFSD2A
Associated Diseasesneurodegeneration
InteractionsPDGFRB, CANCER, NF-ΚB, NEUROINFLAMMATION, PROINFLAMMATORY CYTOKINES, CAVEOLIN-1
KG Connections54 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (17)

SIRT1-Mediated Epigenetic Restoration of MFSD2A Expression R
Score: 0.50
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (4)

Angiogenesis Pathway
mechanism · KG edge: inhibits
Packard Center for ALS Research
institution · KG edge: expressed_in
Alzheimer Indonesia
institution · KG edge: expressed_in
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: expressed_in

Knowledge Graph (12 edges)

MFSD2A inhibits PDGFRB
MFSD2A regulates Ischemia
MFSD2A activates Stroke
MFSD2A activates Ms
MFSD2A regulates Blood-Brain Barrier
MFSD2A inhibits CANCER
MFSD2A inhibits Tumor
MFSD2A inhibits Colorectal Cancer
MFSD2A inhibits Cancer
MFSD2A inhibits Als