gene 2,260 words KG: MS4A6A 2026-03-25
kind:genesection:genesstate:published
Contents

MS4A6A Gene

🧬 Gene Info
Gene SymbolMS4A6A
Full NameMembrane Spanning 4-Domains A6A
Chromosome11q12.2
FunctionMembrane Protein Function: MS4A6A operates as a membrane receptor or scavenger receptor involved in cellular homeostasis
Primary ExpressionMicroglia, B-cells, Myeloid cells
Molecular Weight28 kDa
Amino Acids243 aa
Exons6
UniProt IDQ9H5Z1
NCBI Gene ID64231
Ensembl IDENSG00000110079
GeneCardsMS4A6A
Human Protein AtlasMS4A6A
Associated DiseasesALS, Alzheimer, GLIOBLASTOMA
InteractionsABCA7, PICALM, MS4A4E, CLU, APOE, BIN1
KG Connections211 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (21)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59

Related Analyses (5)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
CD33 Modulation Therapy for Neurodegeneration
idea · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with

Knowledge Graph (12 edges)

MS4A6A provides_data_for ds-83b31ef18d49
MS4A6A associated_with OPTN
MS4A6A associated_with PARK7
MS4A6A associated_with PINK1
MS4A6A associated_with PSEN1
MS4A6A associated_with PSEN2
MS4A6A associated_with SNCA
MS4A6A associated_with SOD1
MS4A6A associated_with TAU
MS4A6A associated_with TBK1