gene 661 words KG: MS4A4E 2026-03-24
kind:genesection:genesstate:published
Contents

MS4A4E Gene - Membrane-Spanning 4-Domains A4E

🧬 Gene Info
Gene SymbolMS4A4E
Full NameMembrane-Spanning 4-Domains A4E
AliasesPage for MS4A4E Gene
Chromosome11q12.2
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionBrain, Spleen, Lymphocytes, Monocytes
UniProt IDQ9NRL3
NCBI Gene ID245722
Ensembl IDENSG00000166908
GeneCardsMS4A4E
Human Protein AtlasMS4A4E
Associated DiseasesAlzheimer
InteractionsCLU, APOE, BIN1, CD2AP, TOMM40, NME8
KG Connections41 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Membrane Cholesterol Gradient Modulators
Score: 0.52
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Lysosomal Membrane Repair Enhancement
Score: 0.45

Related Analyses (4)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (13)

Alzheimer Indonesia
institution · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: co_mentioned
PICALM — Phosphatidylinositol Binding Clathrin Assembly
gene · KG edge: co_mentioned
NME8 Gene
gene · KG edge: interacts_with
MS4A6A Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

MS4A4E interacts_with CLU
MS4A4E interacts_with APOE
MS4A4E interacts_with BIN1
MS4A4E interacts_with CD2AP
MS4A4E interacts_with TOMM40
MS4A4E interacts_with NME8
MS4A4E interacts_with PTK2B
MS4A4E interacts_with MS4A6A
MS4A4E interacts_with PICALM
MS4A4E interacts_with ZCWPW1