gene 924 words KG: NEK7 2026-03-24
kind:genesection:genesstate:published
Contents

NEK7 Gene

🧬 Gene Info
Gene SymbolNEK7
Protein TypeSerine/Threonine Kinase
FunctionNEK7 is a 34 kDa serine/threonine kinase that plays dual roles in cell biology:
Molecular Weight34 kDa
PathwaysInflammasome
Ensembl IDENSG00000151414
GeneCardsNEK7
Human Protein AtlasNEK7
Associated DiseasesAls, Carcinoma, Encephalitis, Inflammation, Ms, Multiple Sclerosis
InteractionsNLRP3, UBIQUITIN, CGAS, STING, TLR4, RELA
KG Connections144 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Microbial Inflammasome Priming Prevention
Score: 0.58
Lysosomal Enzyme Trafficking Correction
Score: 0.49
Cryptic Exon Silencing Restoration
Score: 0.46
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (14)

IGF2R Protein
protein · KG edge: interacts_with
CREB-independent Neuronal Survival Pathways
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: activates
Autoimmune Hypothesis in Alzheimer's Disease
hypothesis · KG edge: expressed_in
MYD88 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

NEK7 activates NLRP3
NEK7 inhibits NLRP3
NEK7 interacts_with NLRP3
NEK7 associated_with ZNF7
NEK7 interacts_with UBIQUITIN
NEK7 inhibits CGAS
NEK7 inhibits STING
NEK7 inhibits UBIQUITIN
NEK7 associated_with NLRC4
NEK7 therapeutic_target SPR