mechanism 2,025 words KG: GSK3 2026-04-01
kind:mechanismsection:mechanismsstate:published
Contents

GSK3-beta Signaling Pathway

Mechanism Info
NameGSK3
SummaryPage for GSK3-beta Signaling Pathway
Key Genes/ProteinsAKT, MTOR, MAPK, ERK, CDK5
Related DiseasesALZHEIMER'S DISEASE, neurodegeneration
Related PathwaysWnt signaling, Pi3K/Akt Pathway, PI3K/AKT, MAPK signaling, oxidative stress response

Knowledge Graph

Related Hypotheses (30)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Vagal Afferent Microbial Signal Modulation
Score: 0.52
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (8)

iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90
AMPK knockdown validation experiment
exploratory · proposed · Score: 0.88
iPSC-NPC transplantation in ICH animal model
validation · proposed · Score: 0.85
Mouse Cdk5, p35, and p39 mutations in neuronal migration
validation · proposed · Score: 0.80
Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40

See Also (3)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates

Knowledge Graph (12 edges)

GSK3 interacts_with MTOR
GSK3 therapeutic_target NEUROINFLAMMATION
GSK3 associated_with TAU
GSK3 therapeutic_target PARKINSON'S DISEASE
GSK3 contributes_to HUNTINGTON
GSK3 contributes_to HUNTINGTIN
GSK3 therapeutic_target AMYLOID
GSK3 associated_with ALZHEIMER
GSK3 contributes_to HUNTINGTON'S DISEASE
GSK3 associated_with CDK5