protein

CARD14

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CARD14: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

20Connections

0Hypotheses

0Analyses

9Outgoing

11Incoming

Summary

CARD14 is a protein involved in neurodegeneration research. Key relationships include: protects against, inhibits, implicated in. Associated with Alzheimer, Neurodegeneration. Connected to 16 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	CARD14
Chromosome	2q31.1
Function	is a gene encoding a member of the CARD family of that play critical roles in regulating cell death, inflammation, and immune signaling pathways[@jordan2012].
Primary Expression	skin keratinocytes and immune cells, but also shows expression in various tissues including the brain[@chang2018]
Molecular Weight	125 kDa
Pathways	NF-κB, NF-κB signaling
UniProt ID	Q9Y2K7
NCBI Gene ID	15292
Ensembl ID	ENSG00000100916
GeneCards	CARD14
Human Protein Atlas	CARD14
Alias	CARMA2, bPS2
Associated Diseases	neurodegeneration
Interactions	MYC, NF-ΚB, AND, PLIN4, BCL2, MITOPHAGY
KG Connections	20 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CARD14 — AlphaFold Q9Y2K7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CARD14["CARD14 Protein"]
    NFkB["NF-kappaB Signaling"]
    MYC["MYC Oncogene"]
    Mitophagy["Mitophagy Pathway"]
    Alzheimer["Alzheimer's Disease"]
    Neurodegeneration["Neurodegeneration"]
    ALS["ALS"]
    APP["APP Gene"]
    TAU["TAU Protein"]
    BDNF["BDNF"]
    BCL2["BCL2"]
    FGF2["FGF2"]
    PLIN4["PLIN4"]
    AMYLOID["Amyloid Pathology"]

    CARD14 -->|"activates"| NFkB
    CARD14 -->|"activates"| MYC
    CARD14 -->|"inhibits"| Mitophagy
    CARD14 -->|"protects against"| Alzheimer
    CARD14 -->|"protects against"| Neurodegeneration
    CARD14 -->|"interacts with"| ALS
    CARD14 -->|"protects against"| APP

    TAU -->|"protects"| CARD14
    BDNF -->|"protects"| CARD14
    FGF2 -->|"protects"| CARD14
    AMYLOID -->|"protects"| CARD14

    BCL2 -->|"inhibits"| CARD14
    PLIN4 -->|"inhibits"| CARD14
    Mitophagy -->|"inhibits"| CARD14

    style CARD14 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style NFkB fill:#4a1a6b,stroke:#333,stroke-width:2px
    style MYC fill:#4a1a6b,stroke:#333,stroke-width:2px
    style Mitophagy fill:#ef5350,stroke:#333,stroke-width:2px
    style Alzheimer fill:#7d4200,stroke:#333,stroke-width:2px
    style Neurodegeneration fill:#7d4200,stroke:#333,stroke-width:2px
    style ALS fill:#7d4200,stroke:#333,stroke-width:2px
    style TAU fill:#1b5e20,stroke:#333,stroke-width:2px
    style BDNF fill:#1b5e20,stroke:#333,stroke-width:2px
    style FGF2 fill:#1b5e20,stroke:#333,stroke-width:2px
    style BCL2 fill:#ef5350,stroke:#333,stroke-width:2px
    style PLIN4 fill:#ef5350,stroke:#333,stroke-width:2px

Outgoing (9)

Target	Relation	Type	Str
Neurodegeneration	protects_against	disease	0.65
Alzheimer	protects_against	disease	0.65
Als	interacts_with	disease	0.65
APP	protects_against	gene	0.60
MYC	activates	gene	0.60
Mitophagy	inhibits	pathway	0.60
NF-ΚB	activates	gene	0.60
AND	activates	gene	0.60
Nf-Κb	activates	pathway	0.60

Incoming (11)

Source	Relation	Type	Str
TAU	protects_against	gene	0.60
FGF2	protects_against	gene	0.60
PLIN4	inhibits	gene	0.60
BDNF	protects_against	gene	0.60
BCL2	inhibits	gene	0.60
MITOPHAGY	inhibits	gene	0.60
NEURODEGENERATION	protects_against	gene	0.60
ALZHEIMER	protects_against	gene	0.60
AMYLOID	protects_against	gene	0.60
GENES	protects_against	gene	0.60
ALZHEIMER'S DISEASE	protects_against	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found