gene 696 words KG: CARD14 2026-03-24
kind:genesection:genesstate:published
Contents

Caspase Recruitment Domain Family Member 14

🧬 Gene Info
Gene SymbolCARD14
Chromosome2q31.1
Functionis a gene encoding a member of the CARD family of that play critical roles in regulating cell death, inflammation, and immune signaling pathways[@jordan2012].
Primary Expressionskin keratinocytes and immune cells, but also shows expression in various tissues including the brain[@chang2018]
Molecular Weight125 kDa
PathwaysNF-κB, NF-κB signaling
UniProt IDQ9Y2K7
NCBI Gene ID15292
Ensembl IDENSG00000100916
GeneCardsCARD14
Human Protein AtlasCARD14
AliasCARMA2, bPS2
Associated Diseasesneurodegeneration
InteractionsMYC, NF-ΚB, AND, PLIN4, BCL2, MITOPHAGY
KG Connections20 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.46
Glycine-Rich Domain Competitive Inhibition
Score: 0.43

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (13)

Tau Protein
protein · KG edge: protects_against
Mitophagy Receptor Pathway in Neurodegeneration
mechanism · KG edge: inhibits
Packard Center for ALS Research
institution · KG edge: interacts_with
Alzheimer Indonesia
institution · KG edge: protects_against
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: protects_against

Knowledge Graph (12 edges)

CARD14 protects_against APP
CARD14 activates MYC
CARD14 protects_against Neurodegeneration
CARD14 protects_against Alzheimer
CARD14 inhibits Mitophagy
CARD14 activates NF-ΚB
CARD14 activates AND
CARD14 interacts_with Als
CARD14 activates Nf-Κb
TAU protects_against CARD14