| Gene Symbol | PPP1CB |
| Chromosome | 2p23.3 |
| Protein Family | Protein phosphatase type 1 family |
| Molecular Weight | 37 kDa |
| Pathways | Epigenetic |
| Ensembl ID | ENSG00000185630 |
| GeneCards | PPP1CB |
| Human Protein Atlas | PPP1CB |
| EC Number | 3.1.3.16 |
| Structure | Catalytic subunit (~37 kDa) |
| [Tau protein](/proteins/tau) | Dephosphorylation at multiple AD-relevant sites (Ser202, Thr231, Ser396) [@mandelkow2004] |
| Glycogen synthase | Regulation of glycogen metabolism |
| Synaptic proteins | Synapsin, PSD-95, AMPA receptor subunits |
| Transcription factors | CREB, c-Jun |
| Tau pathology | PP1-mediated tau dephosphorylation is a key mechanism for reducing tau aggregation and toxicity [@mandelkow2004] |
| Associated Diseases | Als, Inflammation, Parkinson |
| Interactions | CANCER, HK2, NSD3, STAT3 |
| KG Connections | 110 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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